Glioblastoma

Researchers are testing CHANK-101, a therapy made from a patient's own natural killer (NK) cells, in adults with glioblastoma that has returned after standard treatment. The study enrolls 60 participants who receive intravenous infusions of these cells every two weeks for up to 1…

This study tests a custom-made vaccine for people with two serious brain cancers: glioblastoma (GBM) and diffuse intrinsic pontine glioma (DIPG). The vaccine is made from the patient's own immune cells and designed to teach the body to attack the tumor. The main goals are to chec…

Researchers are testing whether adding entacapone to bevacizumab is safe and can slow tumor growth in adults with glioblastoma that has returned after standard treatment. The trial enrolls about 96 participants who have not previously received bevacizumab and for whom repeat surg…

Researchers are testing whether GammaTile, a collagen tile embedded with radioactive cesium-131 seeds, can be safely placed in the brain after surgery for malignant glioma. The trial enrolls elderly or frail patients with newly diagnosed or recurrent tumors. The main goals are to…

This study tests a drug called ADI-PEG 20, which breaks down an amino acid that some brain tumors need to grow. It is given alongside standard radiation and chemotherapy to children, adolescents, and young adults with newly diagnosed high-grade glioma. The goal is to see if this …

This study tests a new treatment called Cerebraca Wafer for people with recurrent glioblastoma, a serious brain cancer. The wafer is placed in the brain during surgery and is followed by standard chemotherapy. The goal is to see if it helps people live longer and controls the dis…

Researchers are testing an investigational oral drug called catequentinib hydrochloride (AL3818) in adults with advanced or metastatic endometrial cancer, low grade serous ovarian cancer, soft tissue sarcoma, or glioblastoma. The trial has two parts: a phase 1b part to find safe …

This early-phase study tests a new treatment for children and young adults with aggressive brain tumors called high-grade glioma and DIPG. The therapy uses the patient's own immune cells, modified in a lab to better recognize and attack tumor cells. The main goals are to see if t…

This study is for adolescents and young adults (ages 12-39) newly diagnosed with aggressive brain tumors called high-grade glioma or DIPG. The goal is to see if a combination of two immunotherapy drugs (relatlimab and nivolumab, sold as Opdualag) is safe and tolerable when given …

This study tests a new treatment called 4sCAR-DLL3 CAR-T cells for people with DLL3-positive brain tumors, including glioblastoma and certain midline gliomas. The therapy uses a patient's own immune cells, modified to target and attack tumor cells. The trial will enroll 30 partic…

This phase 1 trial tests whether FPS-ZM1, a drug that blocks an inflammation pathway, can safely control brain swelling that often occurs after surgery for glioblastoma, a type of brain cancer. Researchers will give FPS-ZM1 with or without the steroid dexamethasone to about 24 ad…

This trial tests whether adding hyperbaric oxygen therapy to a standard immunotherapy-chemotherapy combination can help people with newly diagnosed glioblastoma. Participants receive either adebrelimab plus temozolomide alone, or the same drugs with hyperbaric oxygen sessions. Th…

This trial is testing whether two oral drugs, avutometinib and defactinib, can be safely given to people with newly diagnosed high-grade gliomas, a type of aggressive brain cancer. Participants first take the drugs for one cycle before starting standard radiation, and those with …

This early-stage trial tests an investigational drug called CBX-663 in adults with certain advanced cancers that have not responded to standard treatment or have returned. The study includes people with blood cancers (like AML, MDS, or CMML), advanced solid tumors, or a type of b…

This early-stage trial is testing a personalized cancer vaccine called BreakVax, designed from each patient's own tumor, in combination with standard chemotherapy and immunotherapy drugs. The goal is to see if this multi-pronged approach can safely and effectively boost the immun…

This trial explores whether a special MRI technique can pinpoint low-oxygen (hypoxic) areas within glioblastoma, a type of aggressive brain tumor. In the first phase, researchers will check if these MRI maps match real tissue samples. In the second phase, they will use the maps t…

This trial tests whether adding levetiracetam, a seizure medication, to the standard treatment for glioblastoma can improve outcomes. Glioblastoma is an aggressive brain cancer with poor survival despite current therapy. The study focuses on tumors with low oxygen levels, which a…

This phase II trial is asking whether adding the drug lenvatinib to the standard STUPP regimen (temozolomide plus radiation) can improve outcomes for people newly diagnosed with a type of brain cancer called glioblastoma that has a specific genetic marker (MGMT promoter methylati…

This trial tests an oral drug called JBI-778 in people with brain metastases, leptomeningeal disease, or recurrent high-grade glioma. The drug is designed to block a protein that may help tumors grow. The study aims to find the safest dose and see if the drug can shrink tumors or…

This early-stage trial tests an experimental drug called CT-179 in people with glioblastoma, an aggressive brain cancer. The study has two parts: one for patients whose cancer has returned, and another for newly diagnosed patients who will also receive radiation therapy. The main…

This study tests a drug called tovorafenib in children and young adults (ages 1 to 39) newly diagnosed with aggressive brain tumors (high-grade glioma or DIPG) that have specific genetic changes. The goal is to see if the drug can help them live longer. About 79 participants will…

This phase II trial tests whether a personalized dendritic cell vaccine targeting the Survivin protein can improve survival in people with newly diagnosed glioblastoma, an aggressive brain cancer. Participants receive the vaccine alongside standard chemotherapy after surgery. The…

This early-phase trial tests a new way to treat recurrent glioblastoma, an aggressive brain cancer. Tiny radioactive beads called SIR-Spheres® are injected into the blood vessels feeding the tumour to deliver radiation directly inside it. The study aims to see if this approach is…

This phase 2 trial tests whether adding nimotuzumab—an antibody that blocks a protein called EGFR—to the standard Stupp regimen (temozolomide plus radiotherapy) can improve outcomes for adults with glioblastoma that was not fully removed by surgery. Participants must have EGFR-po…

This phase III trial compares a new type of MRI, called CEST MRI, to standard MRI for guiding surgery in 60 patients with newly diagnosed glioblastoma. The CEST MRI may detect tumor tissue that standard MRI misses, allowing surgeons to remove more of the cancer. The study will me…

This trial tests a personalized vaccine called YS247 for people with recurrent glioblastoma, an aggressive brain cancer. The vaccine is made from each patient's own immune cells and designed to target unique markers on their tumor. The study aims to see if the vaccine is safe and…

This early-phase trial tests a new combination for recurrent glioblastoma, a fast-growing brain tumor. The treatment pairs Actimab-A, a radioactive antibody that seeks out cancer cells, with cemiplimab, an immunotherapy that helps the immune system attack tumors. About 30 adults …

This pilot study tests whether a device called NaviFUS, which uses ultrasound and microbubbles to temporarily open the blood-brain barrier, can safely help the drug bevacizumab reach recurrent glioblastoma tumors more effectively. Ten adults whose brain cancer has returned after …

This study tests a new approach for recurrent glioblastoma, an aggressive brain cancer. It combines a minimally invasive laser that heats and destroys tumor tissue (LiTT) with an immunotherapy drug called cemiplimab, which helps the immune system attack cancer cells. About 99 par…

This early-phase trial tests a new personalized vaccine called Bvax, made from each patient's own cells, combined with standard chemoradiation for newly diagnosed glioblastoma. The study will enroll 25 people to check safety and see if the vaccine helps control the cancer. It is …

This trial tests whether adding mycophenolate mofetil, a drug usually used in organ transplants, to standard radiation and chemotherapy can help people with advanced glioblastoma live longer. About 422 participants will receive either the standard treatment or standard treatment …

This early-phase study tests a new drug called MT-125 alongside standard chemoradiation in people newly diagnosed with a specific type of glioblastoma (MGMT methylated). The goal is to find a safe dose and see how well the body handles it. About 36 adults will take part, with the…

This study tests whether adding a shingles vaccine and, for some patients, specially grown immune cells (CMV-specific T cells) to standard surgery, radiation, and chemotherapy can help people with glioblastoma live longer. About 230 adults with this aggressive brain cancer will t…

This phase 2 trial tests the drug mirdametinib, alone or with radiation, in people with NF1-related high-grade gliomas (aggressive brain tumors). It includes three groups: those with recurrent sporadic glioblastoma, newly diagnosed NF1-associated glioblastoma, and other NF1-relat…

This early-stage trial tests a new drug called STAR-001 combined with the blood pressure medication spironolactone in about 68 people whose glioblastoma has returned after initial treatment. The goal is to see if the combination is safe and can shrink tumors. Participants receive…

This pilot study tests a new radiation schedule for glioblastoma, a serious brain cancer. Instead of standard daily treatments over many weeks, patients receive a higher dose each day for fewer total sessions, combined with the chemotherapy drug temozolomide. The study aims to se…

This early-stage study tests a new drug called FZ-AD005 in 40 people with aggressive brain tumors (high-grade glioma) that have come back or not responded to treatment. The drug is designed to target and kill cancer cells while sparing healthy ones. The main goals are to find the…

This early-stage trial tests a new cell therapy called TH-CART-027 in 21 adults with recurrent grade 4 glioma, a very aggressive brain cancer. The therapy is given directly into the tumor or brain fluid. The main goal is to check safety and find the right dose, while also seeing …

This early-phase study tests whether combining focused ultrasound with the immunotherapy drug pembrolizumab is safe and feasible for people with recurrent glioblastoma, a severe brain cancer. Only 8 participants with a specific genetic feature (mismatch repair deficiency) will be…

This study tests whether using a smaller radiation target area after glioblastoma surgery can control the tumor while causing fewer side effects. About 79 patients will receive limited-field radiotherapy plus standard chemotherapy. The main goals are to see how many patients are …

This phase II trial tests a personalized dendritic cell vaccine (ZSNeo-DC1.1) combined with standard chemotherapy (temozolomide) in 78 adults with newly diagnosed glioblastoma. Participants receive the vaccine as shots during chemo after surgery and radiation. The goal is to see …

This phase 2 trial tests whether adding a cancer vaccine (UCPVax) with or without an immunotherapy drug (pembrolizumab) to standard treatment can help people with a newly diagnosed, aggressive type of glioblastoma live longer. About 98 adults whose tumors have a specific genetic …

This early-phase trial tests a new type of immunotherapy for recurrent glioblastoma, an aggressive brain cancer. The treatment uses a patient's own immune cells, engineered to target a protein called EGFRvIII found on tumor cells, and modified to work better in the tumor's enviro…

This study tests whether adding NG101m capsules to standard chemoradiation helps people with newly diagnosed glioblastoma live longer. About 52 adults will receive NG101m alongside usual care. The goal is to see if the combination is safe and improves 2-year survival.

This trial tests a new AI device that helps surgeons see brain tumors on ultrasound images during surgery. The AI highlights tumor tissue in real time, which may help remove more of the tumor while protecting healthy brain. The study involves 100 adults scheduled for brain tumor …

This trial is testing two new imaging tracers, called CM500, to see if they can help detect solid tumors anywhere in the body. The tracers are given by injection and then used with PET scans to create detailed images. The study includes healthy volunteers and people with various …

This study explores whether tear fluid can be used to detect tumor-related particles in people with glioblastoma, a type of brain cancer. Brain tumors release tiny particles called extracellular vesicles that can be found in spinal fluid, but collecting spinal fluid is invasive a…

This trial is testing whether a special PET/CT scan that uses a radioactive form of tryptophan can provide better information about gliomas (a type of brain tumor) than standard MRI. The study has three parts: seeing if the scan can better define the tumor for radiation planning,…

This study explores whether analyzing tumor DNA in cerebrospinal fluid can help doctors make better treatment decisions for people with malignant brain tumors or brain metastases from lung or breast cancer. Participants undergo a standard spinal tap or fluid collection, and the f…

This study tests whether oxygen-enhanced MRI (OE-MRI) can identify low-oxygen (hypoxic) regions in high-grade gliomas, the most common and aggressive adult brain cancers. Twenty-five patients will undergo OE-MRI scans before, during, and after standard radiotherapy. Researchers w…

This study tests a new group self-management program for adults with brain cancer. The goal is to see if the program is practical and helps improve mental health and quality of life more than standard care. Researchers will compare changes in well-being between the group program …

This study tests a stepped-care model to support relatives of people with acquired brain injury or malignant brain tumor. The model offers basic support to all, with extra help for those who need it, based on screening. Researchers will measure changes in caregiver burden and wel…

This early-stage study tests whether a special MRI that highlights acidic areas can help surgeons see and remove more of an aggressive brain tumor called glioblastoma. The study involves 12 VA patients with newly diagnosed or recurrent glioblastoma. The main goal is to check if t…

This study investigates whether exposure to pesticides influences how aggressive a type of brain tumor called glioblastoma is and how well patients respond to treatment. Researchers will collect urine, hair, and optional blood samples from 120 adults newly diagnosed with glioblas…

This study tracks how the experimental drug AZD1390 moves through and leaves the body after a single dose. It involves about 8 adults with advanced solid tumors who are not currently on active cancer treatment. By using a tiny radioactive label, researchers can measure the drug i…

This study looks at how glioblastoma, a serious brain cancer, changes the way brain cells communicate and use energy. Researchers will use special PET and MRI scans to map these changes in 80 adults before and after surgery. The goal is to link scan results with thinking and memo…

This study looks at how the immune system changes in people with glioblastoma, an aggressive brain cancer, after they have surgery and chemotherapy. Researchers will take blood samples over six months to measure immune cells and signals. The goal is to understand the body's immun…

This study tests whether using MRI scans to plan radiotherapy is better than using CT scans alone. Researchers will work with up to 150 cancer patients and 15 healthy volunteers to see if MRI can make treatment more precise and reduce side effects. The goal is to improve how tumo…

This study tests a new type of MRI called Field-Cycling Imaging (FCI) to see if it can tell the difference between real tumor growth and pseudo-progression (which looks like tumor but isn't) in adults with glioblastoma. Eighteen patients will get both a standard MRI and an FCI sc…

This study tests whether special MRI scans can spot where brain tumors have spread into nearby healthy tissue, which standard scans miss. About 20 adults with suspected high-grade glioma will get extra scans before surgery. The results will be compared to tissue samples to see if…

This early-stage trial will test whether an oral drug called gallium maltolate can reach brain tumors in people with recurrent glioblastoma. Eight participants will take the drug for about two weeks before surgery, and researchers will measure gallium levels in the removed tumor …

This early study tests whether a small device can safely collect fluid from the brain during planned surgery for glioma or epilepsy. Six participants will have the device placed temporarily during their operation. The goal is to see if the device works and is safe, not to treat t…

This study looks at how male hormones (androgens) influence the immune cells around glioblastoma tumors, the most common and aggressive brain cancer in adults. Researchers will collect blood, saliva, and stool samples from 40 newly diagnosed patients before and after standard che…

This study tests giving chemotherapy before radiation for people with high-grade gliomas, a type of aggressive brain tumor. The goal is to see if this approach works well and makes MRI scans easier to read, since radiation can change how the brain looks. About 70 adults aged 18-8…

This study tests a special microscope accessory called GLOW400 that helps surgeons see glowing brain tumors during surgery. About 37 adults with suspected high-grade gliomas will take part. Surgeons will rate how well the device shows tumor fluorescence and image quality. The goa…

This study will include 30 people newly diagnosed with glioblastoma, the most common and aggressive brain tumor. Researchers will use a special MRI technique called magnetic resonance spectroscopy (MRS) to measure chemicals in the tumor, and also test blood for certain markers. T…

This study will follow 50 adults with glioblastoma, an aggressive brain cancer, to see how the amount of tumor removed during surgery affects how long they live. All patients will receive standard radiation and chemotherapy after surgery. The goal is to better understand which su…

This study will follow 100 adults with glioblastoma, an aggressive brain cancer, to understand which factors influence survival. Researchers will collect data on patient characteristics, tumor features, surgical methods, and outcomes. The goal is to identify the best surgical str…