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Narrower radiation after brain tumor surgery aims to spare healthy tissue

NCT ID NCT07368283

Disease control Sponsor: Jiangxi Provincial Cancer Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether using a smaller radiation target area after glioblastoma surgery can control the tumor while causing fewer side effects. About 79 patients will receive limited-field radiotherapy plus standard chemotherapy. The main goals are to see how many patients are alive without tumor growth at 6 months and to measure serious brain damage from radiation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
limited-field radiotherapy plus temozolomide chemotherapy
What this could lead to
If successful, this approach could reduce long-term brain side effects from radiation while still controlling the tumor.
What could go wrong
This is a small, early-phase study with no control group, so results may not be definitive. The limited radiation field might also miss some cancer cells, increasing the risk of recurrence.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 79 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2026

An estimate. Start dates often move.

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged between 18 and 70 years. * Diagnosed with glioblastoma by surgical pathology, with the extent of resection achieving maximal safe resection. * Within 2 to 6 weeks after surgery * In good physical condition with a Karnofsky Performance Status (KPS) score ≥ 60. * Hematological, hepatic, and renal functions are essentially normal. * Signed informed consent, willing to undergo treatment and follow-up as stipulated in the study protocol. Exclusion Criteria: * Prior history of cranial radiotherapy or other malignant tumors. * Severe dysfunction of vital organs (e.g., heart, liver, kidneys) that precludes tolerance to radiotherapy. * Active infection, immune system disorders, or other serious chronic diseases. * Pregnancy or lactation. * Psychiatric disorders or severe cognitive impairment that compromises the ability to cooperate with treatment and follow-up.

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Conditions

The condition(s) this trial relates to.

glioblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Glioblastoma (GBM)

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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