Gastroesophageal reflux disease

This study looks at people with atrial fibrillation (an irregular heartbeat) who have already had a successful mitral valve repair. It compares two approaches: catheter ablation (a procedure to fix the heart's electrical signals) versus standard medical care. The goal is to see i…

This trial tests whether adding a gel made with alginate, licorice, and blueberry to a standard reflux medicine improves symptoms and quality of life in adults with non-erosive gastroesophageal reflux disease (NERD). About 140 participants will receive either the standard medicin…

This study tests a drug called esomeprazole, given through an IV, to prevent stress ulcers and acid reflux in 50 adults recovering from surgery in the intensive care unit (ICU). The goal is to see if it can keep stomach acid low enough to reduce the risk of bleeding. Participants…

This trial is testing a new device called MRace to repair a leaky mitral valve in people with severe functional mitral regurgitation, a condition where the valve doesn't close properly, causing blood to flow backward. The device is placed through a vein in the leg and guided to t…

This study tests a new device called MRace, designed to repair severe mitral regurgitation—a condition where the heart's mitral valve doesn't close properly, causing blood to leak backward. The device is implanted through a vein in the leg, avoiding open-heart surgery, and is aim…

This study tests a new device called MRace, designed to repair a leaky mitral valve in the heart without open surgery. The device is placed through a vein in the leg and guided to the heart to help the valve close properly. The trial will include up to 15 people with severe mitra…

This trial tests whether converting a prior sleeve gastrectomy to a procedure called intestinal transit bipartition can improve stomach emptying, reduce acid reflux, and help with weight control. Forty adults who had sleeve gastrectomy and now have weight regain or reflux will un…

This trial tests whether an experimental drug called JP-1366 can prevent the return of erosive esophagitis in people whose condition has already healed. About 384 adults aged 19 to 75 will take either JP-1366 or the standard drug lansoprazole daily for 24 weeks. The goal is to se…

This phase 1 trial tests two experimental oral drugs, UI059 and UIC202201, in healthy adult volunteers to see how safe they are and how well they control stomach acid. Each participant takes one drug daily for a week, then switches to the other after a break. The goal is to compa…

This study tests whether a digital bottle cap called FORTISKAP™ can detect missed doses of proton pump inhibitors (PPIs) in people with GERD more accurately than standard methods like pharmacy fill records or patient questionnaires. Fifty adults with GERD who take a daily PPI wil…

This trial tests whether adding a 3D holographic visualization tool, called EchoPixel Holographic Therapy Guidance, helps doctors perform two common heart procedures more accurately. The procedures are left atrial appendage occlusion (for atrial fibrillation) and mitral valve rep…

This pilot study tests whether injecting a patient's own fat-derived cells into the lower esophagus is safe and feasible for treating GERD that doesn't respond well to medication. Fifteen adults with chronic acid reflux will undergo a minimally invasive endoscopic procedure. The …

This trial tests a new surgical method called Alinasser's technique for repairing symptomatic hiatal hernia. The procedure uses a mesh to rebuild the ligament that normally holds the esophagus in place, aiming to reduce the chance of hernia recurrence. Sixty adults who have not r…

This study tests a new device called DragonFly M2 to repair leaky mitral valves in people with moderate-to-severe or severe mitral regurgitation who are at high risk for surgery. The device is inserted through a blood vessel, avoiding open-heart surgery. The study will check if t…

This study compares two versions of a minimally invasive procedure called POEM for treating achalasia, a swallowing disorder. The standard POEM often causes severe heartburn afterward. The new version, Sling-Fiber Preserving POEM, aims to reduce that risk by leaving certain stoma…

This study tests a new, single-use endoscope for a procedure called ECCL, which tightens the valve between the stomach and esophagus to treat GERD. Researchers will compare the disposable scope to traditional reusable scopes in 46 adults with hard-to-treat reflux. The goal is to …

This study tests a new device called the HighLife TSMVR system for people with severe mitral regurgitation, a condition where the heart's mitral valve leaks. The device is placed through a catheter via a vein, avoiding open-heart surgery. The trial will include 240 participants w…

Researchers are testing whether early symptom relief from tegoprazan can help diagnose gastroesophageal reflux disease (GERD). Adults with frequent heartburn or acid regurgitation take tegoprazan or a placebo once daily for one week. By comparing symptom improvement between the g…

This study tests whether placing a pH monitoring probe closer to the stomach (1 cm above the squamocolumnar junction) instead of the standard 6 cm position improves detection of acid reflux in women and people with lower body weight. Participants receive two probes simultaneously…

This phase 2 trial tests whether a combination of fosamprenavir (an HIV medication) and sodium alginate (a seaweed-based thickener) can ease heartburn and regurgitation in people whose reflux doesn't improve with standard acid-blocking pills. Sixty adults aged 18 to 65 will take …

Researchers are testing whether placing small bands in the lower esophagus can create a barrier against stomach acid and ease GERD symptoms. The trial enrolls people with symptomatic GERD who have not had previous reflux surgery. Participants undergo an endoscopic procedure to pl…

Achalasia makes it hard to swallow because the valve between the esophagus and stomach stays tight. Researchers randomly assign 220 adults with newly diagnosed achalasia to two procedures that cut that valve muscle: POEM, done through the mouth with no skin cuts, or laparoscopic …

This trial tests whether vonoprazan, taken as needed, can quickly relieve heartburn episodes in adults with non-erosive gastroesophageal reflux disease (GERD). Participants will take either vonoprazan or a placebo when they experience heartburn, and researchers will track how wel…

This study tests whether a daily breathing exercise program can reduce symptoms and improve quality of life in people with non-erosive reflux disease (NERD). Sixty participants will either do high-resistance breathing exercises or a sham version with no resistance for 8 weeks. Re…

This study tests whether a small, non-invasive device that delivers mild electrical pulses to the skin can reduce heartburn in people with Non-Erosive Reflux Disease (NERD). 204 participants will be randomly assigned to receive either real stimulation or a sham (inactive) treatme…

This study tests a traditional Chinese herbal formula called Chaizhi Hewei Decoction for people with non-erosive reflux disease (NERD), a type of acid reflux without visible damage. The trial will randomly assign 66 adults to receive either the herbal granules or a placebo for 4 …

This study compares two surgical techniques to relieve severe heartburn (GERD) in people who have already had sleeve gastrectomy weight-loss surgery. About 35 participants will receive either a ligamentum teres cardiopexy or a gastric bypass. The goal is to see which surgery bett…

This study tests whether gentle electrical stimulation on acupoints can reduce stomach acid backing up into the throat during general anesthesia with an i-gel breathing tube. About 116 adults having surgery will be randomly assigned to receive the stimulation or no stimulation. T…

This study compares two types of heart valve surgery: a newer, less invasive method through a small cut on the right side of the chest versus the traditional method through a cut down the middle of the chest. Researchers will measure how quickly patients recover, including time o…

This study looks at whether two types of breathing training can reduce symptoms of gastroesophageal reflux disease (GERD) in adults. About 51 participants will be randomly assigned to do volume-oriented incentive spirometry, diaphragmatic breathing exercises, or usual care for 6 …

This study tests a new drug called JP-1366 for people with non-erosive gastroesophageal reflux disease (NERD), a condition causing heartburn without visible damage to the esophagus. About 321 adults will take either JP-1366 or a placebo daily. The main goal is to see if the drug …

Laparoscopic fundoplication relieves reflux for most GERD patients, but 10 to 30 percent still have symptoms or side effects afterward. Researchers at Minia University Hospitals follow 470 adults scheduled for this keyhole surgery, measuring ten factors before the operation such …

This study looks at whether people with acid reflux or a hiatal hernia can safely skip a test called esophageal manometry before their surgery. The test, which involves a thin tube through the nose to measure throat muscles, can be uncomfortable and delay surgery. Researchers wil…

This study looks at how severe GERD symptoms are linked to posture problems, muscle pain, and physical activity in adults aged 18 to 65. Researchers will measure symptoms, take posture photos, and ask about pain and exercise. No treatment is given—the goal is simply to understand…

This study will collect data from 10,000 people undergoing upper endoscopy to build an AI model that predicts the risk of developing stomach or esophageal cancer. Researchers will combine information from endoscopy images, tissue samples, genetics, and gut bacteria. Participants …

This study looks at whether measuring bile acids and pepsin in saliva can help identify people who develop acid reflux or esophageal damage after sleeve gastrectomy (a type of weight-loss surgery). About 60 adults will give saliva samples before surgery and again 1 and 3 years af…

This study looks at whether using a stomach ultrasound before sedation can help anesthesiologists make safer decisions for chronic pain patients. These patients often take opioids or have other conditions that slow stomach emptying, raising the risk of food or liquid entering the…

This study compares how two weight-loss surgeries—gastric bypass and sleeve gastrectomy—affect acid reflux in 128 obese patients. Participants will be randomly assigned to one surgery, and their reflux will be measured before and after using a 24-hour pH test. The goal is to see …

This study will examine how metabolic syndrome—a cluster of conditions like high blood pressure, high blood sugar, and excess belly fat—relates to gastroesophageal reflux disease (GERD). Researchers will enroll 50 adults with metabolic syndrome and use an endoscopy to check for s…

This study looks at how obesity and gastroesophageal reflux disease (GERD) are connected. Researchers will measure how common obesity is among 200 adults with GERD. The goal is to better understand the link between these two conditions.