Herbal tea may replace acid pills for reflux sufferers
NCT ID NCT07518420
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a traditional Chinese herbal formula called Chaizhi Hewei Decoction for people with non-erosive reflux disease (NERD), a type of acid reflux without visible damage. The trial will randomly assign 66 adults to receive either the herbal granules or a placebo for 4 weeks. Researchers will measure symptom improvement, quality of life, and aim to see if the formula can help reduce the need for standard acid-reducing drugs.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Chaizhi Hewei Decoction (herbal formula)
- What this could lead to
- If it works, this could offer a natural alternative to reduce or stop acid-reducing medications for people with non-erosive reflux disease.
- What could go wrong
- This is a small early-stage trial with only 66 participants. The herbal formula may not work better than placebo, and side effects like diarrhea are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 66 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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May 2026
An estimate. Start dates often move.
- Expected to finish
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Aug 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Meet thediagnosis criteria for NERD; 2. GERD Q scale score \>8 points; 3. Meet the criteria for the liver-stomach disharmony syndrome in traditional Chinese medicine; 4. Age between 18-70 years old; 5. Participants are informed and voluntarily sign the informed consent form. - Exclusion Criteria: 1. Patients with active gastric or duodenal ulcers, gastritis with active bleeding, severe dysplasia of the gastric mucosa, or suspected malignancy; patients with achalasia or post-achalasia surgery; and patients with functional heartburn. 2. Patients with severe primary diseases of the cardiovascular, hepatic, renal, hematological, or respiratory systems, or malignant tumors. 3. Patients with mental disorders (e.g., schizophrenia, bipolar affective disorder, depression, anxiety, obsessive-compulsive disorder) and those with intellectual or language impairments. 4. Pregnant or breastfeeding women. 5. Patients allergic to any components of this preparation. 6. Patients currently taking medications that may affect the outcome of this study (e.g., proton pump inhibitors, potassium-competitive acid blockers, Tongjiang granules, etc.). 7. Patients currently participating in or having participated in other drug clinical trials within the past 4 weeks. 8. Patients with suspected or confirmed history of alcohol or substance abuse, anxiety, or depression; or, according to the investigator's judgment, other conditions that may reduce the likelihood of enrollment or complicate the enrollment process, such as frequent changes in work environment that may lead to loss of follow-up. \-
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Xiyuan Hospital of China Academy of Chinese Medical Sciences
Beijing, Beijing Municipality, 100091, China
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