Female stress incontinence

This study tests a special scaffold placed during prostate removal surgery to help men regain bladder control. About 266 men will be randomly assigned to get the scaffold or standard care. The goal is to see if the scaffold reduces urine leakage and improves quality of life over …

This study compares two medical sling devices used to treat stress urinary incontinence in women. About 300 women will receive either a single-incision sling or a standard transobturator sling. Researchers will check how well each device stops urine leakage during a cough test an…

This trial tests whether sildenafil, a drug that improves blood flow and muscle strength, can help postmenopausal women with stress or mixed urinary incontinence. The idea is that sildenafil may reduce pelvic floor muscle atrophy, improving symptoms. Participants take sildenafil …

This study compares two treatments for stress urinary incontinence (leaking urine when you cough, sneeze, or exercise). One group gets a shot of platelet-rich plasma (PRP) made from their own blood, while the other gets a standard surgical sling. The trial will enroll 42 women an…

This study follows about 200 women who had surgery with the GYNECARE TVT EXACT sling to treat stress urinary incontinence (leaking urine when coughing or sneezing). Researchers check if the sling still works 5 to 10 years later by using a cough test and patient questionnaires. Th…

This early-phase trial tests whether a robotic bladder transplant from a deceased donor is feasible and safe for people with severe bladder problems. Only 5 participants will be enrolled. The main goal is to see if the transplanted bladder gets good blood flow. If it works, it mi…

This study follows 100 men who have had prostate surgery and still struggle with stress urinary incontinence (leaking urine when coughing or moving). They receive an adjustable implant called REMEEX to help control leakage. Researchers will track how well it works, side effects, …

This study tests a device called SUI-100 for women aged 22-70 with mild-to-moderate stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). About 130 participants will be randomly assigned to receive either the real device or a sham (fake) treatment. T…

This study compares two types of sling surgery for stress urinary incontinence (leaking urine with cough or sneeze) in women who are also having surgery for pelvic organ prolapse. One sling uses a single incision, the other uses two incisions. The trial will enroll 180 women and …

This early study tests a new artificial urinary sphincter device in 6 men with stress incontinence. The device is implanted to help control urine leakage. Researchers will check how many devices are successfully activated and how many need to be removed or revised within 6 months…

This study tests a new artificial urinary sphincter device in 6 women with stress incontinence (leaking urine during activity). The goal is to see if the device is safe and works well. Researchers will check how many devices need to be removed or fixed, and if pad weight tests sh…

This study tests a new treatment called AMDC-USR (iltamiocel) for women who still have stress urinary incontinence after having surgery for it. The treatment uses the patient's own muscle cells injected into the urinary sphincter to strengthen it. Half of the 96 participants get …

This study compares two surgical treatments for stress urinary incontinence in women: laparoscopic Burch colposuspension and transobturator tape. Sixty adult women who have not improved with non-surgical treatments will be randomly assigned to one surgery. Researchers will check …

This early-phase study tests whether a one-time injection of Botox into the bladder muscle can reduce urine leakage in women with stress urinary incontinence. Twenty women who have not improved with other treatments will receive the injection and be monitored for changes in leaka…

This pilot study is testing a new device called UroRelief for stress urinary incontinence—leaking urine during exercise, coughing, or sneezing. The device is placed inside the urethra through a routine scope procedure. The study will check safety and whether it reduces leakage in…

This study tests a new, simpler laparoscopic surgery for women with pelvic organ prolapse (when pelvic organs drop from their normal position). The goal is to restore anatomy and improve quality of life while reducing risks from surgical mesh. The study involves 60 women aged 30-…

This study was testing a new drug called VMB-100, which is an mRNA that tells muscle cells to produce a protein (IGF-1) to help repair the urethra sphincter. The goal was to improve muscle function and reduce urine leakage in women with moderate stress urinary incontinence. The s…

This study tests whether magnetic stimulation of the pelvic floor can help women with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). About 158 adult women will receive the treatment and report their symptoms using questionnaires. The goal is t…

This study looks at whether adding high-frequency laser therapy to pelvic floor muscle training helps women with stress urinary incontinence. Thirty-six women will be split into three groups: exercises alone, exercises plus real laser, or exercises plus a fake laser. Researchers …

This pilot study tests whether weekly testosterone injections can increase pelvic floor muscle size and improve stress urinary incontinence in women aged 60 and older. The trial involves 30 participants and uses MRI to measure muscle changes. It is a small, early-stage proof-of-c…

This study tests whether a laser applied to the vagina can help women with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). About 144 women will receive the laser treatment and be followed for 6 months. The main goal is to see if the treatment r…

This study looks at whether adding diaphragmatic breathing to standard Kegel exercises can improve pelvic floor muscle strength and quality of life in women who have had multiple pregnancies and suffer from stress urinary incontinence (leaking urine when coughing, sneezing, or ex…

This study tests whether a 2-minute perineal massage before a pessary exam can reduce pain and discomfort. 68 women with prolapse or incontinence will try both massage and a gel-only method at separate visits. The goal is to find a simple, non-drug way to improve comfort during r…

This study tests whether a mobile app and a connected device can help women aged 55 and older with stress urinary incontinence do pelvic floor exercises at home. The app guides exercises and provides feedback on muscle contractions. The goal is to see if this approach reduces lea…

This study tests a new device called PelviSense that helps women with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising) strengthen their pelvic floor muscles using biofeedback. About 132 women aged 18-60 will either use the device with standard ex…

This study looks at whether starting pelvic floor physical therapy before prostate surgery (HoLEP) helps men regain bladder control more quickly after the procedure. About 72 men who are already scheduled for HoLEP to treat an enlarged prostate will be randomly assigned to start …

This study tests whether group physiotherapy is as good as individual sessions for treating urinary incontinence in women aged 60 and older. Over 360 participants will receive either weekly group classes or one-on-one therapy for 12 weeks, both focusing on pelvic floor exercises …

This observational study looks at whether high-impact sports, like running or jumping, are linked to urinary incontinence in young adults aged 18 to 35. Researchers compare six groups: men and women who do high-impact sports, those who are physically active but avoid high-impact …

This registry follows women who received iltamiocel — an experimental cell therapy — for stress urinary incontinence that came back or persisted after surgery. Researchers are tracking long-term safety and whether the benefit lasts. The goal is to see if this one-time treatment c…

This study looks at how blood flow to the urethra relates to bladder control. Researchers will use special ultrasound imaging in 70 women—35 with stress urinary incontinence and 35 without—to compare blood supply and pressure measurements. The goal is to better understand what ca…

This study follows over 1000 men across Europe who had surgery for stress urinary incontinence (leaking urine with coughing, sneezing, or activity). The two surgeries being tracked are the artificial urinary sphincter and the male sling. Researchers will collect data for up to 10…