Fatty liver disease

This Phase 3 trial tests whether efimosfermin alfa can improve liver fibrosis in adults with compensated cirrhosis caused by MASH (a fatty liver disease). Participants receive either the drug or a placebo via injection. The main goal is to see if liver scarring improves by at lea…

This phase 3 study tests whether an experimental drug called efimosfermin alfa can prevent serious liver complications in adults with compensated cirrhosis due to MASH (metabolic dysfunction-associated steatohepatitis). Participants receive either the drug or a placebo as a shot …

This large phase 3 study is testing whether two drugs, tirzepatide and retatrutide, can prevent major liver complications in 4,500 adults with high-risk metabolic fatty liver disease (MASLD). Participants are randomly assigned to receive one of the drugs or a placebo for about 4 …

This study tests a new drug, pegozafermin, in 1,350 adults with MASH (a type of fatty liver disease) and moderate liver scarring (stage F2 or F3). The goal is to see if the drug can improve scarring or resolve liver inflammation without making the disease worse over 52 weeks. Par…

This Phase 3 study tests an experimental drug called pegozafermin in 762 adults with liver scarring (cirrhosis) caused by MASH, a fatty liver disease. Participants receive weekly injections of the drug or a placebo for about two years. The goal is to see if the drug can improve l…

This study looks at how the liver responds to food and a drug called semaglutide in people with non-alcoholic fatty liver disease (NAFLD). About 84 adults, including healthy volunteers, will take part. Researchers will check if semaglutide can reduce liver fat and damage over 30 …

This study tests whether eating 50 grams of peanuts daily for 12 weeks can improve liver markers and gut health in adults with metabolic fatty liver disease (MASLD). 125 participants will be randomly assigned to either eat peanuts or stick to their regular diet. Researchers will …

This study tests a new drug, GSK4532990, in about 393 adults with liver inflammation from alcohol use. The goal is to see if it safely reduces liver stiffness and improves liver function over 52 weeks. Participants receive either the drug or a placebo, and researchers monitor sid…

This early-stage trial is testing whether alirocumab, a drug approved for high cholesterol, is safe for heavy drinkers and might reduce liver inflammation. One hundred healthy adults who drink heavily will receive either alirocumab or a placebo injection over 8 weeks. Researchers…

This study tests whether Taiwan green propolis, a natural bee product, can improve blood lipids and body fat in adults with metabolic dysfunction-associated steatotic liver disease (MASLD), a common fatty liver condition linked to obesity and high cholesterol. About 60 participan…

This study tests whether taking a low dose of niacin (vitamin B3) after meals can help reduce fat stored in the liver for people with metabolic fatty liver disease (MASLD). Researchers will compare niacin to a placebo in 36 adults aged 50 to 80. The goal is to see if niacin can r…

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by 70%, can help reverse fatty liver disease (MASH) in people with obesity. Researchers will compare ESG plus lifestyle changes to lifestyle changes alo…

This study tests whether a daily orange peel fermentation supplement can lower body fat in 124 overweight adults with fatty liver. Participants take one sachet per day for two months. Researchers will measure changes in body fat, cholesterol, and other health markers.

This study tests whether a low dose of digoxin, a drug normally used for heart problems, can help people with a severe type of fatty liver disease called NASH (also known as MASH). The trial will involve 144 adults with biopsy-confirmed NASH and liver scarring. Participants will …

This study tests whether a 4-week ketogenic diet before liver surgery can reduce fat in the liver and lower the need for blood transfusions. About 124 adults with fatty liver and colorectal cancer that spread to the liver will either follow the diet or get standard dietary advice…

This study looks at whether drinking instant coffee every day for 6 weeks can reduce liver fat and improve gut health in people who have finished treatment for stage I-III colorectal cancer. About 80 adults who completed surgery, chemo, or radiation at least 2 months ago will par…

This study tests an experimental drug called ALN-PNP in healthy adults and people with a liver condition called MASLD who have a specific gene variant. The main goal is to check safety and how the body handles the drug. It is a first-in-human trial, so the drug is not yet approve…

This study is testing whether a multi-strain probiotic supplement, taken alongside standard lifestyle advice, can improve liver health in people with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). The trial will enroll 80 adults with elevated liver enzymes and …

This early-stage trial tests an experimental drug called NNC0581-0001 in 48 adults with fatty liver and suspected liver inflammation. Participants receive three monthly injections of either the drug or a placebo. The main goal is to check safety and how the drug moves through the…

This study tests whether a daily injection of tesamorelin can safely reduce liver fat in adults with metabolic fatty liver disease (MASLD). About 120 participants will receive either the drug or a placebo for 52 weeks, along with lifestyle advice. The main goal is to measure chan…

This study tests a new medicine called NNC4005-0001 to see if it is safe and tolerable for people with extra body weight and too much fat in the liver. About 60 adults will get either the medicine or a placebo (a dummy pill) just once. The study lasts about 7 to 8 months and focu…

This pilot study tests whether milk thistle, an herbal supplement, can improve fatty liver disease in children aged 9 to 22. Twenty participants will receive either milk thistle capsules or a placebo, plus lifestyle advice. The goal is to see if milk thistle lowers liver enzymes …

This study tests an experimental pill called HP515 for people with non-alcoholic fatty liver disease (NAFLD). About 80 adults aged 18 to 65 with at least 10% liver fat will take the drug for 12 weeks. The main goal is to see if it reduces liver fat measured by MRI, while also che…

This pilot study tests whether time-restricted intermittent fasting can lower liver fat in non-obese adults (BMI 23-30) with non-alcoholic fatty liver disease (NAFLD). Researchers will measure liver fat changes using advanced imaging and track quality of life. The goal is to find…

This study tests whether erdosteine, a drug usually used for lung conditions, can help people with nonalcoholic fatty liver disease. Fifty adults with fatty liver will receive either standard care (diet and exercise) or standard care plus erdosteine. Researchers will measure chan…

This Phase 3 trial tests whether hydroxychloroquine, a drug used for malaria and autoimmune diseases, can improve nonalcoholic steatohepatitis (NASH), a type of fatty liver with inflammation. 210 adults with confirmed fatty liver and elevated liver enzymes will take either 200 mg…

This early-stage trial tests whether cilostazol, a drug used for leg pain, can help people with nonalcoholic fatty liver disease (NAFLD). About 50 adults with fatty liver will take the drug to see if it reduces liver fat and lowers fibrosis risk scores. The study aims to find a n…

This phase 2 trial tests whether nicotinamide (a form of vitamin B3) can stop or reverse liver fibrosis in people with non-alcoholic fatty liver disease and obesity. Thirty adults will take either nicotinamide or a placebo daily for one year. Researchers will measure liver stiffn…

This study tests if a tube-like device called a stent, placed through a scope, can reverse gastric bypass surgery in 20 people who have serious complications like low blood sugar, blockages, or liver problems. The goal is to see if the stent works as well as surgery to fix these …

This study is testing a new automated MRI method to see if it can take clearer pictures of the liver. It will include up to 200 adults (and some children age 7+) who are healthy, have known or suspected liver disease, or have iron overload. Participants will have one MRI scan, an…

This study is testing whether a non-invasive tool, called bioimpedance vector analysis, can predict fatty liver disease (MASLD) in healthy volunteers. Researchers will use machine learning to analyze body composition data from about 2000 adults aged 18 to 80. The goal is to creat…

This study is testing a new ultrasound technique called visual transient elastography (ViTE) to measure liver fat and scarring in people with chronic liver injury. Researchers will compare the ultrasound results to the standard liver biopsy to see how accurate the new method is. …

This study is looking at whether a blood test called the Enhanced Liver Fibrosis (ELF) test can find early signs of fatty liver disease in people who are at high risk, such as those with diabetes, high blood pressure, or heart disease. Researchers will review medical records of 3…

This study compares two newer imaging methods—photon-counting CT and ultrasound—against the standard MRI to see how well they detect fat and scarring in the liver. About 45 adults with liver disease will receive all three scans. The goal is to find a faster, cheaper, and equally …

This study is testing whether advanced ultrasound techniques can accurately detect fatty liver disease (MASLD) in children aged 9 to 18. Researchers will compare ultrasound results to MRI scans and blood tests in 120 children with risk factors for the condition. If the ultrasound…

This pilot study is testing a new Thermoacoustic Enhanced Ultrasound device to measure fat in the liver. Researchers will compare the device's readings to the gold-standard MRI measurement in 49 adults with fatty liver disease. The goal is to develop a more accessible and afforda…

This study is testing a new ultrasound method to measure fat in the liver without needles or expensive scans. It involves 110 adults with or at risk for MASLD, a common liver condition linked to obesity and diabetes. If successful, this tool could make liver health checks easier …

This study is testing a new ultrasound technology called DeepUSFF to measure fat in the liver of people with metabolic fatty liver disease (MASLD). Researchers will compare the ultrasound results to MRI scans, which are the current gold standard. If the ultrasound works well, it …

This trial tests whether following a Mediterranean diet for 12 weeks can reduce fat buildup in the liver of healthy young adults aged 20 to 30. Participants are randomly assigned to either a Mediterranean diet or a standard healthy diet, and liver fat is measured using ultrasound…

This study looks at how the liver processes fat in people with alcohol use disorder who are quitting drinking. Researchers will take two small liver samples—one early in detox and one after four weeks—to compare gene activity. The goal is to understand how the liver clears fat wh…

This study tests how a single injection of HRS-4729 behaves in people with mild, moderate, or severe kidney impairment compared with healthy people. Researchers measure drug levels in the blood over time to see if kidney function affects how the body processes the drug. The trial…

This study follows 1,500 pregnant women and their children for up to 18 years to understand how a mother's health, lifestyle, and environment affect her child's growth and risk for obesity, diabetes, and fatty liver. Mothers attend visits during pregnancy and after birth, while c…

Researchers at Beijing Friendship Hospital are following 500 adults with biopsy-confirmed nonalcoholic fatty liver disease for up to 10 years. The study measures liver stiffness and liver fat every six months using imaging and blood tests. The goal is to understand which factors …

This study looks at how the hormone insulin controls blood sugar and fat in healthy adults and those at risk for type 2 diabetes. Researchers will give participants a single dose of a drug called alpelisib, which blocks some of insulin's effects, to see if the liver can still mak…

This study looks at how exercise changes the amount of sugar the liver makes in people with type 2 diabetes and fatty liver disease. Researchers will measure liver sugar production during rest and exercise in 12 adults aged 25-55. The goal is to better understand how exercise hel…

This study investigates how immune cells in fat tissue, called macrophages, handle fats and whether this affects metabolism in people with obesity. Researchers will compare adults with obesity and type 2 diabetes or fatty liver to lean individuals, using imaging, blood tests, and…

This trial asks whether fructose, a sugar found in fruit and processed foods, causes more liver inflammation in people with MASH (a serious fatty liver disease) than in those with milder fatty liver or no liver disease. Over four weeks, participants follow a low-sugar diet and th…

This study follows 250 people newly diagnosed with HIV and 161 healthy volunteers over five years to see who develops metabolic fatty liver disease (MASLD). Researchers use annual blood tests, ultrasounds, and FibroScans to measure liver fat and stiffness. The goal is to uncover …

This study looks at how common fatty liver disease is in people with Cushing's syndrome, a rare condition caused by too much cortisol. Using MRI and FibroScan, researchers will measure liver fat at diagnosis and again one year after cortisol levels return to normal. The goal is t…

This observational study aims to see if frailty—a state of increased weakness and vulnerability—differs between men and women with MASLD (fatty liver disease). Researchers will track 140 participants over time using physical tests and questionnaires. No drugs or treatments are be…

This study looks at whether people born with a low birth weight have a higher chance of developing non-alcoholic fatty liver disease (NAFLD) as adults. Researchers will compare 250 low-birth-weight adults with 50 normal-birth-weight adults using liver scans and other tests. The g…

This early-stage study tests a single dose of an experimental drug called efimosfermin alfa in 32 adults with fatty liver disease and varying degrees of liver damage. The goal is to see how the drug moves through the body and whether it is safe. Participants must have liver cirrh…

This study looks at how cutting calories affects the way the liver processes amino acids, sugars, and fats in people with type 2 diabetes. Researchers want to see if weight loss helps the liver respond better to a hormone called glucagon. About 20 adults with type 2 diabetes and …

This study looks at how semaglutide, a drug used for diabetes and weight loss, changes fat tissue around the kidneys, heart, and liver in people with type 2 diabetes and chronic kidney disease. Researchers will compare patients taking semaglutide to those not taking it. The goal …

This study looks at whether exercising before breakfast (fasted) or after breakfast (fed) is better for people with type 1 diabetes. Over 12 weeks, 20 participants will do combined resistance and aerobic training three times a week. Researchers will track insulin doses and blood …

This study aims to understand how liver diseases like fatty liver, hepatitis B, fibrosis, and cirrhosis develop by analyzing individual liver cells and their spatial organization. Researchers will collect blood and discarded liver tissue from 240 patients undergoing surgery or bi…

This study is re-examining 1,400 adults in Stockholm to find early signs and risk factors for heart, lung, and liver diseases. Participants will get advanced scans, blood tests, and questionnaires. The goal is to better understand how these diseases develop and how to predict the…

This study looks at how eating a lot of fructose (a type of sugar) changes the bacteria in your gut and affects your risk for type 2 diabetes and fatty liver. Thirty adults with obesity, diabetes, or fatty liver will eat a high-fructose or high-glucose diet for 12 days, then swit…

This study looks at medical records from 15,000 people to see how chronic liver diseases (like hepatitis, fatty liver, and cirrhosis) are linked to other health problems. Researchers will track new cases of liver cancer and complications over time. The goal is to better understan…