Disorder of acid-base balance

This study compares two drugs, sodium bicarbonate and THAM, for treating metabolic acidosis in patients after heart surgery. About 250 adults who develop acidosis after using a heart-lung machine will be randomly assigned to receive one of the two drugs. The main goal is to see i…

This study tests a drug called veverimer in 150 adults with moderate-to-severe chronic kidney disease (CKD) and a condition called metabolic acidosis, where acid builds up in the blood. The goal is to see if the drug can raise blood bicarbonate levels and improve physical functio…

This study tests whether giving sodium bicarbonate (baking soda) intravenously can reduce major kidney problems or death in critically ill patients with metabolic acidosis and acute kidney injury. About 660 adults in intensive care will receive either sodium bicarbonate or a stan…

This study compares a nasal high-flow device to standard non-invasive ventilation (NIV) for treating people who come to the emergency room with a severe COPD flare-up and high carbon dioxide levels. Participants are randomly assigned to receive one of the two breathing supports f…

Thick meconium in the amniotic fluid affects about 1 in 7 pregnancies and can cause breathing problems in newborns. The PEARL trial tests whether infusing warm sterile fluid into the uterus during labor reduces these risks. The study will enroll 320 pregnant people at 36 weeks or…

This study tests whether taking sodium bicarbonate (baking soda) daily can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will receive either sodium bicarbonate or a…

This study tests whether adding urea to the dialysis fluid can prevent dialysis disequilibrium syndrome — a set of neurological symptoms like headache, confusion, and seizures — in people with kidney failure who need urgent dialysis for severe electrolyte problems. Researchers wi…

This study tests a new bedside test that uses a single drop of blood to diagnose methanol poisoning, a major problem in low-income countries. The test measures formate, a toxic byproduct of methanol, and could give results in minutes instead of hours. The trial will first check h…

This observational study looks at factors that influence bicarbonate levels in people on maintenance hemodialysis for end-stage renal disease. Researchers will collect data on demographics, medical history, diet, and dialysis details, and measure bicarbonate levels before and aft…

This study looks at two common IV fluids given to children aged 6 months to 5 years who are dehydrated from a stomach bug. The goal is to see if one type helps restore normal blood chemistry faster than the other. Doctors choose the fluid as part of normal care, and the research …

This study looks at how different fluids used to fill the heart-lung machine before heart surgery affect the body's balance. 80 adults having bypass or valve surgery will be split into four groups, each receiving a different priming solution. Researchers will track changes in aci…