Disorder of acid-base balance

This study tests two common methods to treat metabolic acidosis—a condition where blood becomes too acidic—in people on long-term hemodialysis for kidney failure. One group takes oral sodium bicarbonate capsules, while the other gets a higher bicarbonate concentration in their di…

This study tests whether taking sodium bicarbonate (baking soda) tablets twice a day for a month can prevent blood pressure from rising during dialysis. It involves 40 chronic hemodialysis patients who already experience blood pressure spikes during treatment. The goal is to see …

This study measures how often metabolic acidosis, an imbalance in blood acidity, appears in children admitted to a pediatric intensive care unit. Researchers will track 140 children aged 1 month to 18 years, using blood gas tests at admission to spot the condition. They will also…

Doctors in the ICU often check blood gases through an arterial line, but that carries risks like clots and infection. This study asks whether blood drawn from a central venous line, which is already in place for other care, gives equally useful information. Researchers will compa…

This study tests whether a non-invasive device called indirect calorimetry—which measures carbon dioxide production and elimination through breathing—can accurately reflect changes in blood bicarbonate levels in critically ill patients. Currently, bicarbonate is measured through …

This study looks at 100 adults who needed a breathing machine after a heart attack or cardiac arrest. Researchers want to see how often acid-base problems happen and compare the settings doctors used with those suggested by a computer algorithm. The goal is to improve future care…

This study watches how carbon dioxide gas, used to inflate the belly during laparoscopic weight-loss surgery, changes blood bicarbonate levels. Researchers will track 85 adults having sleeve gastrectomy or gastric bypass to see if these changes relate to how long the gas is used …