Chronic kidney disease

This pilot trial investigates whether potassium citrate can improve bone quality and strength in adults and children with chronic kidney disease. Participants take either potassium citrate or a placebo for six months, along with blood and urine tests and advanced bone scans. The …

People with chronic kidney disease (CKD) often have an overactive sympathetic nervous system, which raises their risk of heart problems and death. This phase 4 trial tests whether pioglitazone, a drug usually used for diabetes, can reduce that nerve overactivity and improve blood…

This study tests a single dose of ravulizumab given before heart surgery to see if it can prevent kidney damage and serious kidney problems in people with chronic kidney disease. About 736 adults will take part. The goal is to reduce the risk of major kidney events within 90 days…

This study tested a liquid medicine called paricalcitol in children aged 0 to 9 years with severe kidney failure who are on dialysis. The goal was to see if it safely lowers high parathyroid hormone levels, a common complication. The trial was stopped early after enrolling only 2…

This study looked at whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) could help people with diabetic kidney disease. The goal was to see if it could improve kidney function and reduce protein in the urine. However, the study was stopped early an…

This small Phase 2 study tested two doses of vonafexor, an oral drug, in 10 people with mild-to-moderate chronic kidney disease and suspected MASH (a type of fatty liver disease). The goal was to see if vonafexor could improve kidney function. However, the trial was terminated ea…

This small pilot study tested whether a low-carb diet (50-100 grams of carbs per day) combined with the diabetes drug dapagliflozin could improve blood sugar control in people with chronic kidney disease and prediabetes or type 2 diabetes. Four participants were split into two gr…

This phase 2 study tested a weekly extended-release capsule of calcifediol (CTAP101) in 44 adults with chronic kidney disease on hemodialysis who also had vitamin D insufficiency and secondary hyperparathyroidism. The goal was to see if the drug could raise vitamin D levels and l…

This study looked at whether taking a daily low-dose aspirin could help people with chronic kidney disease avoid their first heart attack or stroke. Over 4,600 participants were randomly assigned to take aspirin or receive usual care. The trial was stopped early, and the final re…

This study tested a drug called sodium zirconium cyclosilicate (SZC) to see if it could slow down chronic kidney disease (CKD) in people who also have high potassium levels. Over 1,100 adults with moderate-to-severe CKD took SZC or a placebo alongside their regular blood pressure…

This study looked at whether two drugs, finerenone and empagliflozin, can slow kidney function decline in people at high risk for chronic kidney disease after having a kidney removed for cancer. Ten participants took one or both drugs or no drug for a year. The trial was terminat…

This study tested a device called everlinQ endoAVF that creates a connection between an artery and a vein using a thin tube (catheter) instead of open surgery. The goal was to make it easier for people with chronic kidney disease to get dialysis. The trial enrolled 100 adults who…

This study tested whether a drug called imlifidase, given with other medications, could prevent the immune system from attacking a new kidney in highly sensitized patients. These patients have a very high risk of rejecting a donated kidney. The study was stopped early after only …

This early study tested a new drug called AZD5462 added to the standard medicine dapagliflozin in people with heart failure and moderate kidney disease. Only 8 participants were enrolled before the study was stopped. The goal was to see if the combination is safe and affects how …

This early study tested a drug called isatuximab in 23 people waiting for a kidney transplant. The goal was to see if it could safely lower immune antibodies that make it hard to find a matching donor. The trial was stopped early, so we have limited information on how well it wor…

This study tested a drug called KBP-5074 in 652 adults with moderate-to-severe chronic kidney disease and high blood pressure that was not controlled by at least two other medications. Participants received either KBP-5074 or a placebo daily for up to 52 weeks to see if the drug …

This study investigates why people with advanced chronic kidney disease (stages 3b to 5) often feel tired and weak. Researchers measure handgrip strength and muscle electrical signals in patients aged 60 and older, comparing them to healthy individuals of the same age and sex. Th…

This study looked at whether special eye scans (OCT-angiography) can predict how well the remaining kidney will work one year after kidney removal for cancer. Researchers enrolled 30 adults scheduled for total nephrectomy. The goal was to see if retinal blood vessel patterns coul…

This study looked at how the drug tacrolimus, often used after kidney transplants, affects blood sugar and insulin in people with kidney failure who are waiting for a transplant. Researchers wanted to find early signs of diabetes risk so doctors could adjust treatment. The study …

This study aimed to find substances in blood and urine that could signal kidney damage earlier than current tests. Researchers compared samples from healthy volunteers, people with low fluid levels, those at high risk for kidney failure, and patients with acute kidney failure. Th…

This study compared survival in people with end-stage kidney disease who were randomly assigned to either peritoneal dialysis or hemodialysis. The goal was to see which type of dialysis leads to longer life and fewer complications. The study was conducted in China and was termina…

This study aimed to see if teaching chronic kidney disease patients about their condition in a pharmacy could help them choose a dialysis type or consider a transplant. It was designed for adults in Arkansas who were not yet on dialysis. The study was stopped early after only one…

This study looked at why erythropoietin (EPO), a drug used to treat anemia, can raise blood pressure in people with chronic kidney disease. Researchers planned to enroll 160 participants but stopped early with only 27. The goal was to measure changes in blood pressure and blood v…

This pilot study tested a home-based conservative care program for veterans with advanced chronic kidney disease who chose not to start dialysis. The program involved a team of doctors, nurses, and other specialists providing care at home. Only 2 participants were enrolled before…