Cerebrovascular disorder

This study compares standard medical care to a new, less invasive surgery for people with a severe bleeding stroke. The surgery uses a small tube to drain the blood clot and delivers clot-busting medicine directly into the brain. Researchers want to see if this approach helps pat…

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This trial investigates whether daphnetin, a compound from certain plants, can improve cognitive function in people with vascular cognitive impairment—a condition where reduced blood flow to the brain affects memory and thinking, but not yet dementia. Participants aged 50-80 with…

This study is a registry that will follow about 200 people with brain aneurysms who are treated with a flow diverter device (p64, p64 MW, or p48 MW). The goal is to see how safe and effective these devices are in real-world practice across France. Participants will be monitored f…

This phase 3 trial tests whether tegoprazan, a stomach acid blocker, can prevent gastrointestinal complications like bleeding and ulcers in people who have had an ischemic stroke and are taking antiplatelet drugs (blood thinners). About 1,500 adults in South Korea will receive ei…

This study tests whether a non-invasive device that gently stimulates the vagus nerve through the ear can reduce inflammation and brain swelling after a hemorrhagic stroke (intracerebral hemorrhage). The trial enrolls adults with a specific type of brain bleed and compares the ac…

This study tests a special sealant called Immiseal that is applied during brain or spine surgery to prevent leaks of cerebrospinal fluid. It is used along with standard repair methods to create a watertight seal. The study follows adults aged 18 to 75 who need dural repair after …

This study tests a nurse-led program called BEST CARE ICTUS_HC for adults hospitalized with acute stroke in hospitals without specialized stroke units. The program includes staff training, swallowing tests, and environmental adaptations to help with attention and safety. Research…

This study tests whether a structured care bundle—including rapid blood pressure control, reversal of blood thinners, and management of fever and blood sugar—can improve outcomes for people with a brain bleed. About 3500 adults in Sweden and Australia will receive either the care…

This study tests whether giving a clot-busting drug called tenecteplase directly into the brain artery after mechanical clot removal helps people recover better from a severe stroke. About 462 adults with a large vessel blockage in the front part of the brain will be randomly ass…

This study is testing a non-invasive device that stimulates the vagus nerve (a major nerve in the neck) to see if it is safe and helpful for people who have had a severe bleeding stroke called aneurysmal subarachnoid hemorrhage. About 25 adults in the intensive care unit will rec…

This trial is testing a drug called tenecteplase for people with a severe stroke caused by a blockage in the basilar artery at the back of the brain. About 688 participants will receive either tenecteplase or standard care within 24 hours of symptoms starting, followed by a clot-…

This study looks at whether a procedure to remove a blood clot from the brain (endovascular therapy) can help people who had a mild stroke but then got worse because of a large blockage. The treatment is given more than 24 hours after the stroke started. About 272 adults with mil…

This study is testing whether giving a clot-busting drug (tenecteplase) directly into the blocked brain artery can improve outcomes for people having a stroke caused by a medium-sized vessel blockage. About 282 participants will be randomly assigned to receive either the intra-ar…

This study is testing whether metformin, a common diabetes medicine, can reduce the risk of death, heart attacks, and strokes in veterans who have pre-diabetes and already have heart or blood vessel disease. About 7,410 participants will receive either metformin or a placebo. The…

This early-stage trial tests whether nicotinamide riboside (a form of vitamin B3) can improve blood flow and brain function in people with smooth muscle dysfunction syndrome (SMDS), a rare genetic condition that narrows arteries and can cause strokes. Fifteen participants will ta…

This Phase 3 trial tests whether the drug Dimephosphon can improve recovery in people who have had an acute ischemic stroke. About 184 adults aged 35-80 will receive either Dimephosphon or a placebo within 24-72 hours of their stroke. The main goal is to see if more patients achi…

This study tests whether a non-invasive treatment called remote ischemic conditioning (RIC) can help people recover after surgery for a ruptured brain aneurysm. RIC involves using a blood pressure cuff on the leg to create brief, harmless blood flow interruptions, which may trigg…

This study tests whether lowering blood pressure can slow the growth of white matter lesions in the brains of older adults (60-88) with high blood pressure and memory complaints. About 820 participants will receive either standard care or an enhanced blood pressure lowering strat…

This study tests a portable EEG device called StrokePointer that ambulance crews can use to detect severe strokes caused by large vessel blockages. Currently, over half of these patients are taken to hospitals that cannot perform the needed clot-removal procedure, causing an aver…

Researchers are comparing two LDL cholesterol targets in adults who have had a small vessel occlusion stroke, a type of stroke caused by blocked small arteries deep in the brain. Participants receive standard cholesterol-lowering drugs, with or without ezetimibe or PCSK9 inhibito…

This study tests whether combining a gentle brain stimulation technique (tDCS) with repetitive arm and hand exercises can help people who have neglect after a stroke. Neglect means they have trouble paying attention to one side of their body or space. The study also aims to combi…

This study tests a new type of mirror therapy to help people who have had a stroke regain movement in their arm and hand. The therapy uses a mirror to show the unaffected arm moving, which tricks the brain into thinking the affected arm is moving too. 81 participants will receive…

This study tests a low-intensity brain stimulation method called kTMP to help people who had a stroke at least 12 months ago improve arm and hand movement. About 12 adults aged 18-80 with moderate arm weakness will receive kTMP alongside motor rehabilitation. The goal is to see i…

This pilot study tests whether a 4-week home-based cognitive strategy training program can help adults with chronic stroke become more independent in daily activities like dressing and cooking. Eighteen participants will work with an occupational therapist in their own homes. The…

This early-phase trial tests whether inhaled nitric oxide is safe for people having emergency clot removal after a stroke. It includes 36 adults with severe strokes. The main goal is to find the highest safe dose without causing brain bleeding.

This study tests two new therapy systems that use virtual reality (VR) or mixed reality (MR) to help stroke survivors improve arm function. Participants will perform movements while watching a mirrored hand in a headset. The trial aims to see if these high-tech approaches are fea…

This pilot study tests whether drinking beetroot juice daily for two weeks can improve memory and brain blood flow in 25 people with small vessel disease and diabetes. The juice is rich in nitrate, which the body can convert to nitric oxide, a molecule that helps blood vessels wi…

This study tests whether a 24-week home exercise program, guided by a coach over video calls, can improve brain connections and physical fitness in people aged 60 and older who have had a lacunar stroke. Sixty participants will be split into two groups: one starts exercise right …

This study looks at how social and lifestyle factors—like education, race, and income—affect a person's thinking and memory after a stroke. Researchers will interview 450 adults who had a stroke and review their brain scans and medical records. The goal is to understand why some …

This study looks at how brief mental stress affects heart function and brain health in 450 adults aged 40-60. Participants complete two sessions: one with stress tests and heart monitoring, another with brain scans and memory tests. The goal is to understand links between stress …

This study is for adults 18 and older who have had a stroke or a transient ischemic attack (TIA), often called a mini-stroke. The goal is to collect information from standard medical tests and some extra research tests, like blood draws and brain scans, to better understand how t…

This study will measure a protein called BD-tau in the blood of 100 people who have had an acute ischemic stroke. Researchers will take blood samples every hour for 48 hours to see how the protein levels change over time. The goal is to better understand brain injury patterns and…

This study is looking for biological markers (biomarkers) in blood, urine, spinal fluid, and other samples that could help predict who will have a stroke and how they will recover. Researchers will follow 7,000 people with and without ischemic cerebrovascular disease for up to 4 …

This observational study investigates why some people develop epilepsy after a stroke, while others do not. Researchers will compare first-time stroke patients with healthy volunteers using brain imaging (MRI), electrical brain recordings (EEG), and overnight sleep studies. The g…

This study looks at how stroke changes the way the spinal cord handles sensory signals. Researchers will stimulate nerve roots in the neck during surgery and measure muscle and brain responses in 15 people (some with stroke, some healthy). The goal is to better understand spinal …

This study is creating a large database of health information from 743 adults with HIV/AIDS across Brazil. Researchers will look at how common chronic diseases like heart disease, kidney disease, and cancer are in this group. The goal is to gather data to help improve health poli…

This study tests whether a live video call between a neurologist and emergency medical technicians (EMTs) can improve the accuracy of stroke detection in the ambulance. About 512 adults with suspected stroke will take part. The goal is to see if video assistance helps diagnose st…

This study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…

This study from the University of Oxford looks at why women who had high blood pressure during pregnancy are more likely to develop heart and blood vessel disease later in life. Researchers will follow 200 women who gave birth 10 to 25 years ago, using heart scans, exercise tests…

This study looks at people with brain damage from strokes, tumors, or other conditions to understand why they have specific thinking problems. Researchers will use brain scans and cognitive tests to link brain areas to deficits. The goal is to learn more about how the brain works…

This study uses magnetoencephalography (MEG), a non-invasive brain scan, to compare brain signals in 1,500 children with neurodevelopmental disorders (like epilepsy, autism, ADHD) and healthy children. The goal is to improve diagnosis and understanding of these conditions. No tre…

This study collects blood, clots, and tissue from up to 1000 people having procedures for stroke or other blood vessel problems in the brain. Researchers will analyze these samples to find biological markers and understand inflammation. The goal is to learn more about how stroke …

This study tests a special microscope attachment called GLOW800 that helps surgeons see blood flow and tissues in real time during brain and reconstructive surgery. About 29 adults will take part, and surgeons will rate how well the tool works. The goal is to confirm the device i…

This early study is testing whether a robot can help doctors perform delicate brain blood vessel procedures, such as angiography, embolization, and thrombectomy. Ten patients scheduled for these standard procedures will have them done using a robotic system instead. The main goal…

This study will follow 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). Some were taking blood thinners when they had their stroke, others were not. Researchers want to understand why blood thinners fail in some patients, by looking at …