Cardiomyopathy

This study looks at whether the drug eplontersen can reduce abnormal protein buildup in the heart for people with a condition called ATTR-CM. About 150 participants from a larger trial will get heart scans after 140 weeks of treatment. The goal is to see if the drug helps clear t…

This trial is testing an experimental drug called eplontersen in people with transthyretin-mediated amyloid cardiomyopathy (ATTR CM), a condition where abnormal protein builds up in the heart and leads to heart failure. The study aims to see if the drug, given as a regular inject…

This study looked at whether using a blood test (NTproBNP) to guide heart-protecting medications can safely prevent heart damage in people with breast cancer or lymphoma receiving anthracycline chemotherapy. About 108 adults participated, and researchers measured how many joined,…

This study tested a new way to help heart failure patients with weak hearts get the right medications. Over 2,400 people with a heart device took part. A nurse used a simple checklist to guide doctors in prescribing better treatments, aiming to reduce hospital visits and improve …

This phase 3 trial tested the drug patisiran in 360 people with ATTR amyloidosis with cardiomyopathy, a condition where abnormal protein builds up in the heart, making it stiff and weak. Participants received either patisiran or a placebo intravenously. The study measured how far…

This study tested whether eating tuna-based nuggets for three months could improve health in 120 people with heart disease and related conditions like obesity and diabetes. The nuggets were given as a source of selenium. Results showed improvements in some markers of inflammation…

This study tested a new computer simulation, called a 'virtual heart,' to help doctors find the best spots to burn heart tissue (ablation) in patients with ventricular tachycardia (VT) caused by prior heart attacks. Ten adults with VT and scarred heart muscle were enrolled. The a…

This early-stage trial tests NTLA-2001, a CRISPR-based gene editing therapy, in 72 adults with hereditary ATTR amyloidosis—a condition where abnormal protein builds up in nerves or the heart. The treatment aims to turn off the faulty gene to reduce protein levels. The study focus…

This study tested a new drug called OMT-28 in 28 people with primary mitochondrial disease, a condition that affects how cells produce energy. Participants took the drug once daily for 6 months, and researchers measured safety, blood markers of inflammation, and symptoms like fat…

This completed Phase 3 trial tested whether dobutamine, a heart-strengthening drug, can reduce organ failure in 136 ICU patients with septic cardiomyopathy and low blood flow. Patients received either dobutamine or a placebo alongside standard care. The study measured changes in …

This early-phase study tested whether the heart medication carvedilol could safely protect breast cancer patients from heart damage caused by chemotherapy drugs like doxorubicin and trastuzumab. 68 women with early-stage breast cancer were assigned to either receive carvedilol or…

This study investigates whether advanced heart imaging and blood tests can detect early signs of heart damage in adults who received anthracycline chemotherapy as children. Anthracyclines are effective cancer treatments but can increase the risk of cardiomyopathy years later. Cur…

This study tested whether a special heart scan (SPECT) can predict how well patients with ischemic cardiomyopathy will recover after heart surgery. 120 patients underwent imaging at rest and during stress to measure heart function and blood flow. The goal was to find patterns tha…

This study compared two contrast agents (Dotarem and Gadovist) used in cardiac MRI to see which provides clearer images of heart muscle damage. 120 adults with coronary artery disease or cardiomyopathy received one of the two dyes during their scan. Researchers rated image qualit…

This pilot study tested whether a portable 6-lead ECG device, paired with an artificial intelligence algorithm, can help screen first-degree relatives of people with dilated cardiomyopathy (a weakened heart muscle). The goal was to see if this mobile approach could detect reduced…

This study tested whether nebivolol, a beta-blocker heart drug, could prevent heart failure in 51 boys aged 10-15 with Duchenne muscular dystrophy. Participants had normal heart function at the start and were randomly given either nebivolol or a placebo. The trial found that nebi…

Researchers are testing whether a hybrid cardiac rehabilitation programme can help adults recover after heart surgery. Participants start with two weeks of supervised exercise at the hospital, then continue training at home for six weeks using heart-rate monitors, a cloud care pl…

This study looks at whether aggressive weight loss using semaglutide can improve symptoms in people with a specific type of heart failure linked to obesity. About 81 participants with a BMI of 30 or higher and heart failure with preserved ejection fraction will receive either sem…

This study tested the drug dapagliflozin (a diabetes medicine) in 50 adults with heart failure due to amyloid cardiomyopathy, a rare condition where abnormal proteins stiffen the heart. Researchers measured changes in quality of life, walking distance, and heart stress markers ov…

This early-stage study will check if two different tablet forms of the drug HRS-1893 are processed the same way in the body. Thirty-six healthy adults will take both versions and have blood tests to measure drug levels. The goal is to see if the two formulations are equivalent, n…

This study uses MRI scans to measure amyloid protein buildup in the hearts of up to 150 people with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM). Participants are already enrolled in a larger treatment trial. The goal is to see how amyloid levels change over time, not …

This completed study looked at 260 patients with ischemic cardiomyopathy (a weak heart due to blocked arteries) who had heart surgery. The goal was to develop a personalized approach to choose the best type of surgery and predict risks and outcomes. Researchers used imaging, bloo…

This study collected information from over 15,000 people hospitalized with cardiomyopathy, a heart muscle disease. Researchers looked at how much these hospital stays cost and what the money was spent on. The goal was to understand the real-world financial impact and help manage …

This study looked at how certain genes in blood cells respond to environmental exposures in 178 healthy volunteers aged 18 to 45. Researchers measured gene activity to better understand links to inflammation, cancer, and other diseases. The goal was to gather knowledge, not to pr…

This study looked at how the body absorbs a new drug called HRS-1893, which is being developed for heart muscle disease (cardiomyopathy). 38 healthy adults took different versions of the tablet, with and without food, to see which form works best and if food changes how much drug…

This completed study looked at 60 heart failure patients with reduced pumping function and dangerous heart rhythms. Researchers compared metabolic profiles between those with ischemic (blocked arteries) and non-ischemic (other causes) heart disease. By analyzing blood samples, th…

This study tested whether using cardiac MRI (a type of scan without radiation) can make heart exams safer and more accurate for children with heart failure, heart defects, or who have had a heart transplant. Researchers compared MRI results with standard biopsy and X-ray methods …

This study compared two types of exercise training for people who had a heart attack: continuous moderate exercise and intermittent high-intensity exercise. One hundred participants completed an 8-week program, and researchers used ultrasound to measure changes in heart function.…

This study used advanced MRI scans to look at the hearts of 276 people with chronic kidney disease, including those on dialysis. The goal was to identify different types of heart damage and link them to patient outcomes. No new treatment was tested; instead, researchers aimed to …

This completed study looked at how the beta-blocker carvedilol helps the heart pump better in people with heart failure. Fifty-five patients with weak hearts took the highest tolerated dose for six months. Researchers measured changes in heart muscle contraction to understand the…

This study tested new MRI methods to detect bleeding inside the heart muscle after a heart attack. Researchers studied 14 patients to see if these scans could better identify damage that raises the risk of heart failure. The goal was to improve imaging, not to test a treatment.