Cannabis dependence

This trial tests whether allowing adults in Basel to buy cannabis from pharmacies, instead of the illegal market, changes how much they use and their mental and physical health. About 374 adults who use cannabis at least monthly will be randomly assigned to either regulated pharm…

This study tests a brief computerized and smartphone-based program designed to help regular cannabis users with Cannabis Use Disorder better handle emotional stress. The goal is to see if the intervention reduces distress intolerance and cannabis use compared to a health educatio…

This phase 2 trial tests whether psilocybin, the active compound in magic mushrooms, combined with psychotherapy can help adults with moderate to severe cannabis use disorder reduce or stop their cannabis use. Participants receive two doses of psilocybin alongside motivational en…

This study tests a program called MOMENT-V that combines two counseling sessions with a smartphone app to help young adults reduce cannabis use. About 65 participants will either use the full program or have a brief counseling session. Researchers will check if the program is eas…

This study looks at whether allowing regular cannabis users to buy regulated cannabis from pharmacies helps them switch to safer ways of using it, like vaping or edibles, instead of smoking. About 1,177 participants in Switzerland are randomly assigned to buy from pharmacies or s…

This study compares cannabidiol (CBD) to the standard antipsychotic risperidone in 64 adults with schizophrenia or related psychotic disorders who have used cannabis. The goal is to see if CBD can reduce psychotic symptoms and help people stop or cut down cannabis use. Participan…

This study tests whether training store staff and increasing enforcement can reduce marijuana sales to obviously-intoxicated customers. Researchers will send actors pretending to be drunk to buy marijuana and see if stores refuse the sale. The goal is to prevent impaired driving …

This study looks at whether terpenes—natural compounds found in plants—can reduce pain when taken alone or with THC. Researchers will test 45 adults who use cannabis regularly to measure pain relief and any feelings of being high or drug liking. The goal is to find safer ways to …

This study tests whether dronabinol, a synthetic form of THC (the psychoactive compound in cannabis), can reduce severe breathlessness in people with advanced COPD. Thirty participants will receive both dronabinol and a placebo in random order to compare effects. The goal is to s…

This study tests a text-message counseling program designed to help young adults ages 18 to 25 reduce or stop their cannabis use. Participants must use cannabis at least three days a week and live in Tennessee or Colorado. The program uses peer support and counseling delivered vi…

This pilot study tested three different strengths of inhaled cannabis (2.5%, 5%, and 10% THC) against a placebo to see if they could quickly relieve migraine headaches. Twenty adults with migraine took part in a crossover design, meaning each person tried all options. The main go…

This study looks at whether cannabis oil can help reduce pain and improve sleep and quality of life in people with fibromyalgia who have not found relief from other treatments. Researchers will track pain levels, side effects, and how well patients stick to the treatment. The goa…

This study looks at how daily cannabis smoking changes pain sensitivity and the risk of abuse in healthy adults who already use cannabis. Researchers will measure pain tolerance and withdrawal symptoms over 16 days in a controlled hospital setting. The goal is to understand if ca…

This study looks at what happens when people who use cannabis regularly take it daily for two weeks. Researchers will measure pain sensitivity, feelings of a 'good drug effect,' and natural cannabis-like chemicals in the blood. The goal is to understand if daily use changes pain …

This trial explores whether cannabis use changes male reproductive health, including sperm quality, testosterone levels, and genetic markers in sperm. Men who use cannabis regularly and those who don't will be randomly assigned to vape cannabis with different THC doses, a placebo…

This study aims to find out how many pregnant women in Slovenia use alcohol or cannabis by testing their newborns' first stool (meconium) and asking mothers to fill out a survey. Researchers will also compare the gut bacteria of babies exposed to these substances with those who w…

This study will use brain scans to see how cannabis affects inflammation and brain activity in up to 100 U.S. military veterans with PTSD and suicidal thoughts. Participants will take cannabis for 12 weeks and have PET and MRI scans before and after. The goal is to link brain cha…

This phase 1 study evaluates the safety and tolerability of BRC-002, an investigational cannabis-derived botanical drug, in healthy adults aged 18 to 55. Researchers will also examine how the body processes the drug and whether food affects its absorption. The results will guide …

This study aims to understand if cannabis affects pain relief and the risk of abuse differently in men and women. Researchers will give 160 regular cannabis users either active cannabis or a placebo and measure their pain response, drug effects, and blood levels. The goal is to g…

This study looks at medical records of 50 cancer patients who say cannabis helped stop their tumor from growing or shrank it. Researchers want to see if there is real evidence behind these claims. The goal is to gather information, not to test a new treatment.

This study looks at how cannabis use changes natural brain chemicals in adolescents aged 14 to 25. Researchers will measure cannabinoid and endorphin levels in blood to find markers that could tell which teens might relapse and which stay sober. The goal is to better understand c…

This study looks at how small amounts of alcohol and THC (the active part of cannabis) affect driving in a simulator. Forty adults aged 21 to 55 who have used both substances before will take part. The goal is to understand how these drugs change driving performance and thinking,…

This study looks at how alcohol and cannabis, alone or together, affect driving ability and thinking. About 40 occasional cannabis users who also drink alcohol will use a driving simulator after taking controlled doses. The goal is to understand the risks of driving under the inf…

This study looks at how alcohol and cannabis, alone or together, affect driving and thinking. About 40 occasional users aged 21–55 will take part. They will inhale low-dose THC (like a quarter of a joint) and drink alcohol, then test their driving on a simulator and complete ques…

This study at Yale University looks at how THC, the active ingredient in cannabis, affects short-term and long-term memory. Researchers will give 80 adults who have used cannabis before either a low dose of THC or a placebo and then test their memory. The goal is to better unders…

This study looks at how alcohol and cannabis, alone or together, affect driving ability and thinking. About 40 adults aged 21–55 who have used both substances before will take part. They will complete simulated driving tests and questionnaires after receiving the substances. The …

This study looks at whether young adults (ages 21-25) who use high-potency cannabis concentrates can improve their memory and thinking by switching to less potent products. Researchers will test participants' cognitive performance and collect blood and urine samples. The goal is …

This observational study will follow 384 patients in Brazil who are using cannabis-based products (like CBD or THC oils) prescribed by their own doctors for chronic pain, anxiety, or depression. Researchers will not provide the medication but will track patients' quality of life,…

This study looks at how different types of cannabis oil (high or low CBD-to-THC ratio) affect stress and self-control in healthy adults aged 19-35 who use cannabis occasionally. Participants will undergo brain scans and stress tests to measure changes in brain activity, stress ho…

This study aimed to see if a drug called AEF0117 changes how the body processes THC from cannabis. It was designed for healthy adults aged 21-55 who use cannabis. The trial was withdrawn before enrolling anyone, so no results are available.

This study looks at how different patterns of cannabis use (like how often, how long, and what type) affect anesthesia needs and inflammation in people having lumbar spine surgery. Researchers will measure the amount of anesthesia and pain medication needed during surgery, as wel…