Brain injury

This study tests whether adding stem cells to standard cooling therapy helps newborns with brain injury from lack of oxygen at birth. Forty infants will receive either stem cells from donated placentas or a placebo. Researchers will track death and developmental delays for up to …

This trial tests whether epidural spinal cord stimulation can help people with severe brain injury breathe without a ventilator. Ten patients with stroke or traumatic brain injury who need mechanical ventilation will receive a surgically implanted electrode that delivers electric…

This study tests whether giving creatine monohydrate, a popular sports supplement, twice a day for 12 weeks is safe and practical for children and teenagers recovering from a moderate-to-severe brain injury, including traumatic brain injury or stroke. The trial will enroll 46 par…

This trial investigates whether a structured exercise and physical activity program can improve health-related quality of life and daily physical activity in adults who have had an acquired brain injury. Thirty participants will either receive the exercise program plus usual care…

This trial tests whether a rehabilitation program that targets different aspects of balance can improve balance, mobility, walking, and quality of life in adults with acquired brain injury (from stroke, trauma, or other causes). Participants are randomly assigned to either the ba…

This study tests whether giving growth hormone to elderly patients (60+) with moderate to severe brain injury and low blood protein can improve their nutritional status. Half of the 160 participants will get daily growth hormone shots plus standard care, while the other half gets…

This early-phase trial tests whether adding hydrogen gas to standard cooling therapy is safe and feasible for newborns who suffered brain injury from lack of oxygen at birth (HIE). About 54 infants will be randomly assigned to receive either standard cooling alone or cooling plus…

This study tests whether a home-based telerehabilitation program using a virtual reality device can help people recover motor and cognitive skills after a severe acquired brain injury as effectively as in-person therapy. Sixty-two adults aged 18 to 75 with brain injury will be as…

This study tests whether a device that gently stimulates a nerve in the ear can reduce brain damage and inflammation after a traumatic brain injury or bleeding stroke. Sixty adults will be randomly assigned to receive either real stimulation or a sham (fake) treatment. Researcher…

This study tests whether tranexamic acid (TXA), a drug that helps stop bleeding, can improve recovery in 2000 severely injured children with brain or torso injuries. The goal is to see if TXA reduces bleeding and improves quality of life and thinking skills. The trial is for chil…

This study tests whether a portable, radiation-free ultrasound performed at the bedside can accurately detect brain injuries in children, compared to the standard head CT scan. Researchers will enroll 220 children aged 2-17 who are already scheduled for a head CT due to suspected…

This trial tests whether two non-invasive tools can help paramedics detect dangerously high pressure inside the skull in patients with sudden brain injury, such as stroke or head trauma, before they reach the hospital. The tools are a wearable sensor placed on the head and an ult…

This study adapts and validates Italian versions of two clinical scales for patients with disorders of consciousness after severe brain injury. The Brief Evaluation of Receptive Aphasia (BERA) assesses language understanding using eye movements, and the SWallowing Assessment in D…

This study tests a one-year lifestyle program designed to help people with traumatic brain injury lose weight and prevent diabetes. The program includes 22 sessions over a year, focusing on healthy eating and physical activity. Researchers will track weight, blood pressure, and b…

This study tests whether giving anti-epileptic drugs right after a traumatic brain injury can prevent seizures. About 70 adults with moderate to severe head injuries will receive either the drug or standard care. Researchers will track seizure episodes and recovery over 3 months …

This study tests whether a simple pre-game safety huddle—where coaches, referees, and players briefly talk about the importance of reporting concussion symptoms—can improve concussion reporting in youth soccer. Researchers will enroll 2,000 children aged 9-13 and their coaches ac…

This study looks at whether a single dose of the antibiotic ceftriaxone can prevent early pneumonia in 60 brain-injured patients who need a breathing tube. Researchers will measure drug levels in the blood to see if enough reaches the infection site, especially in patients with f…

Researchers compare two rehabilitation approaches for children with cerebral palsy and immature brain injury: virtual reality training and task-oriented circuit training. Both aim to improve upper limb sensorimotor function, pinch grip, and quality of life. Forty-four children ag…

This trial tests a soft, wearable robotic exoskeleton designed to assist arm and hand movements in people with acquired brain injury. Participants, including healthy volunteers, perform a set of arm movements with and without the device's help. The study measures how usable the d…

This study tests a stepped-care model to support relatives of people with acquired brain injury or malignant brain tumor. The model offers basic support to all, with extra help for those who need it, based on screening. Researchers will measure changes in caregiver burden and wel…

This early study tests whether a low-level magnetic therapy device, used at home, is safe and practical for people with cognitive issues from brain injury, Long COVID, or Alzheimer's. About 30 adults will use the device regularly and complete computer-based thinking tests. The go…

This study will test whether a daily aromatherapy massage, combined with a sensory stimulation program, can improve cognitive function in intensive care patients with brain injuries. Sixty adults on ventilators or oxygen will be randomly assigned to receive the treatment from a f…

This study tests whether playing virtual reality games like Beat Saber can improve memory, attention, and thinking speed in people with acquired brain injury. Fifteen participants will do 15 sessions of VR training over 5 weeks, plus their usual rehab. The goal is to see if this …

This study tests if using augmented reality (AR) games can make rehabilitation therapy more engaging for people with acquired brain injury (like from a stroke or trauma). The goal is to see if this fun approach helps patients stick with their therapy, which could lead to better r…

This study will test if guided nature-based therapy, like forest bathing and gardening, can improve the wellbeing of elderly patients with dementia and patients recovering from stroke or brain injury. Researchers will measure changes in agitation, mood, and quality of life in 1,6…

This study tests a program called COMA-F, designed to help caregivers of patients with severe acute brain injury manage emotional distress. The program teaches skills to cope with uncertainty and long-term caregiving challenges. Researchers will compare it to a basic education pr…

This study tests whether a non-invasive brain stimulation technique called tDCS, combined with computer-based cognitive training, can improve memory, attention, and multitasking in veterans with mild traumatic brain injury and PTSD. Forty-six veterans will receive either real or …

This study tests whether virtual reality relaxation sessions can help adults with acquired brain injury who live in nursing homes and have emotional or behavioral issues. Three participants will use a multisensory VR device for 15–20 minutes twice a week over 8 weeks. Researchers…

This study tests a family-centred talking therapy (ACT) for young people aged 11-18 with acquired brain injury and their parents. Up to 6 families will receive 12 online therapy sessions. The goal is to see if the therapy is feasible and can improve emotional wellbeing, psycholog…

This study tests a robotic exoskeleton called CLINICAL EXPLORER in 60 children aged 2 to 17 with neurodevelopmental disorders like cerebral palsy. The device supports walking during 8 therapy sessions. Researchers will check if it is safe, easy to use, and helps improve movement …

This study tests a robotic system that monitors vital signs in patients with severe brain injury. The robot works alongside standard care to detect early signs of decline. Researchers will measure how usable and acceptable the robot is for staff and patients. The goal is to see i…

This study will collect blood samples, brain scans, and medical information from 270 people with penetrating brain injuries. The goal is to create a large research database that scientists can use to better understand these injuries and improve future treatments. Participants mus…

This study aims to translate and adapt an English scale (EmNSA) into French to better assess sensation in the legs of adults with acquired brain injury. Researchers will test the new French version on 50 patients to ensure it is accurate and reliable. The goal is to provide a val…

This study tests a new method that uses carbon dioxide measurements to help doctors set breathing machines more precisely for brain injury patients. The goal is to reduce lung damage while keeping the patient stable. The study will include 30 adults in a neuro-intensive care unit…

This study watches brain activity in 300 adults during high-risk surgeries like heart or spine operations. Researchers use special monitors to track brain waves and pressure, linking them to patient outcomes. The goal is to understand why some people develop confusion or brain in…

This study looks at whether certain proteins in the blood can signal brain injury in children who have heart surgery with a heart-lung machine. Researchers will measure these proteins before and after surgery and compare them to the child's brain function. The goal is to find a s…

This study will follow 10 people aged 6 to 75 with chronic traumatic brain injury who choose to get MUSE stem cell therapy outside the U.S. Researchers will not give any treatment but will track safety, brain function, and quality of life for 12 months. The goal is to gather real…

This study looks at whether an EEG (a brain wave test) can better tell the difference between people who are unresponsive but awake and those who show minimal signs of awareness after a severe brain injury. About 42 adults will take part. The goal is to see if brain responses to …

This study looks at how air moves in the lungs of brain-injured patients when doctors are removing their breathing tube. Using a special imaging belt (electrical impedance tomography), researchers will track changes in lung ventilation patterns. The goal is to find patterns that …

This study will collect detailed information from 200 adults with severe brain injuries treated at Örebro University Hospital. Researchers will track their recovery, including brain function and healthcare needs, for up to a year. No new treatments are being tested—the goal is to…

This study tests whether mild hypothermia (cooling the body to about 33°C) during coronary artery bypass grafting protects the brain better than normal temperature (about 36.5°C). Researchers will use advanced brain scans and blood tests to measure brain injury in 160 adults unde…

This study will test a new robotic and virtual reality system called NeglectARm 3D in 15 people who have spatial neglect after a stroke. The system uses a robot arm and VR headset to measure how well patients notice objects in 3D space. Researchers want to see if the device is ea…

This study will enroll 50 people with severe brain injuries to see if combining different types of monitoring—like blood sugar levels, brain waves, and blood flow—can help predict how well they will recover. Researchers will follow participants for 6 months to check their neurolo…

This observational study tests a new bedside device that measures nucleosome levels in the blood of critically ill ICU patients. Researchers want to see if these levels can predict which patients are likely to die within 30 days. The study will enroll 130 adults with conditions l…

This study will follow 50 people with brain hemorrhage to see if a feature called the 'spot sign' on CT scans can predict who is at higher risk of death or disability. Researchers will compare these scan findings with standard risk scores. The goal is to improve early identificat…