Brain cancer

This early-phase study tests a new treatment for glioblastoma, an aggressive brain cancer. The approach uses a patient's own immune cells, modified in the lab to better recognize and attack the tumor, combined with chemotherapy. The main goal is to check the safety of this therap…

This phase 2 trial tests whether the immunotherapy drug nivolumab can shrink tumors or slow their growth in adults with rare central nervous system (brain or spine) tumors that have returned after prior treatment. Participants receive nivolumab by IV every 2 to 4 weeks for up to …

This study tested a combination of two drugs, pembrolizumab and lenvatinib, in 18 adults with melanoma or kidney cancer that had spread to the brain. Participants had already received anti-PD-1/PD-L1 therapy. The goal was to see if the drug combo could shrink or eliminate brain t…

This phase III trial compared two radiation strategies for cancer that had spread to the brain and returned in new spots after initial radiosurgery. One group received focused radiation only to the new tumors, while the other received whole brain radiation that avoided the memory…

This study tested a combination of two drugs, bintrafusp alfa and pimasertib, in people whose cancer had spread to the brain. The goal was to find the safest dose and see if the treatment could slow or stop the cancer from growing. The trial was stopped early after enrolling only…

This study tested the drug cabozantinib in 19 people with a severe type of brain tumor (grade IV astrocytic tumors) that had come back after initial treatment. The goal was to see if the drug could shrink tumors or slow progression. However, the company stopped the trial early fo…

This study tested a new drug called zotiraciclib (TG02) combined with the standard chemotherapy temozolomide in adults with recurrent anaplastic astrocytoma or glioblastoma. The goal was to find the safest dose and see if the combination worked better than temozolomide alone. The…

This study tested the safety of giving a second dose of an experimental virus (C134) directly into the brain tumor of patients whose malignant glioma had returned. Only one patient was enrolled before the study was stopped. The goal was to see if repeat dosing was safe and tolera…

This trial tested two immune-boosting drugs, tiragolumab and atezolizumab, with or without chemotherapy, in people with non-small cell lung cancer that had spread to the brain. The goal was to see if the combination could control the brain tumors and delay the need for radiation.…

This early-stage trial aimed to see if combining three drugs (tucatinib, trastuzumab, and capecitabine) with precise radiation (SRS) is safe for people with HER2-positive breast cancer that has spread to the brain. Only one person enrolled before the study was terminated, so we h…

This study looked at whether adding the drug pembrolizumab to chemotherapy could help people with a type of lung cancer that has spread to the brain but isn't causing symptoms. The goal was to control the cancer in the brain and body while keeping quality of life. Only 3 people t…

This early-phase trial tested a new immunotherapy approach for children with DIPG, a rare and aggressive brain stem tumor. After standard radiation and chemotherapy, patients received special vaccines and immune cells designed to attack the tumor. The study was small (11 particip…

This early-phase study tested a new drug called PF-07284890, alone or with another drug (binimetinib), in 65 people with advanced cancers that have a specific genetic change (BRAF V600 mutation), including cancers that spread to the brain. The trial was terminated early, but rese…

This study tested a new drug called VAL-083 in people with glioblastoma, an aggressive brain cancer that had returned after standard treatments. The trial aimed to see if VAL-083 could help patients live longer. However, the study was stopped early after only 2 people enrolled, s…

This study tested a special radioactive tracer (68GaNOTA-Anti-HER2 VHH1) to see if it can find HER2-positive brain metastases on PET/CT scans. Seven adult cancer patients with at least one brain lesion were enrolled. The goal was to compare tracer uptake in HER2-positive versus H…

This study tested a new imaging device called cCeLL-Ex vivo that uses laser microscopy to quickly detect brain tumors during surgery. The goal was to see if it could diagnose tumors faster than the standard frozen section method, which takes 20-30 minutes. The study enrolled 285 …

This early-phase trial tested a radioactive imaging agent called 68Ga-FF58 in 14 adults with certain advanced solid tumors (glioblastoma, brain metastases from breast cancer, gastroesophageal cancer, or pancreatic cancer). The goal was to see if the agent could help detect these …

This study tested whether a PET scan using a radioactive tracer called 18F-Fluciclovine can tell the difference between a returning brain tumor and damage from past radiation therapy. Nineteen people with brain metastases who had suspicious MRI findings took part. The goal was to…

This early-phase trial tested whether brivaracetam, a seizure medication, is safe for people with diffuse gliomas (a type of brain tumor). Only 3 participants were enrolled before the study was terminated. The main goal was to track side effects, not to measure tumor shrinkage or…

This early-stage trial tested whether adding a device that creates electric fields (NovoTTF-200M) to standard radiation and immunotherapy is safe for people with melanoma that has spread to the brain. Only one person took part before the study was stopped early. The main goal was…

This study tested a text-message-based diet program called Txt4fasting for people with breast or lung cancer that spread to the brain. The goal was to see if eating only during certain hours could reduce thinking and memory problems after radiation. Only 1 person enrolled before …

This study tested whether injecting a contrast dye and using ultrasound during brain tumor surgery could help surgeons see the difference between tumor and healthy brain tissue. The goal was to remove more of the tumor safely. Only 2 people were enrolled before the study was stop…

This study looked at whether a robotic navigation device can help doctors take brain biopsies accurately. The goal was to see if the robot could achieve a 90% success rate in getting a clear tissue sample. Only 4 people with brain tumors took part before the study was stopped. Th…

This study looked at whether repeated MRI scans and blood tests could predict changes in thinking and memory after brain radiation. Researchers enrolled 9 adults with brain tumors who were scheduled for radiation. They collected blood samples and performed advanced MRI scans over…

This study looked at whether a liquid biopsy—testing the fluid around the brain and spinal cord—can find tumor DNA in children and young adults with brain tumors. The goal was to see if this safer, non-surgical test could replace risky tissue biopsies for diagnosis and monitoring…

This study aimed to track quality of life in 52 patients with brain metastases who received radiosurgery (Gamma Knife). Patients filled out questionnaires before treatment and every 3 months for a year. The study was terminated early, so the full impact on daily life remains uncl…

This early-phase trial tested whether posaconazole, a drug used for fungal infections, can reach brain tumors in high enough amounts to stop cancer cells from dividing. Seven adults with glioblastoma took the drug before surgery, and researchers measured drug levels in their spin…

This early-phase trial tested whether ketoconazole, a drug normally used for fungal infections, can enter brain tumors in high enough amounts to stop tumor cells from dividing. Only 1 person was enrolled before the study was terminated. The goal was to measure drug levels in the …

This study looked at a tiny molecule called microRNA-10b in people with brain tumors called gliomas. Researchers wanted to see if higher levels of this molecule could help predict how the disease might progress or how long patients might live. The study was stopped early, but it …