Bacterial pneumonia

This trial tests whether inhaling bacteriophages, which are viruses that specifically kill Pseudomonas aeruginosa bacteria, can help clear a serious lung infection in patients on breathing machines. The study includes adults with ventilator-associated pneumonia caused by this bac…

This study tests whether a machine-learning system called iAST® can improve how doctors choose antibiotics for patients with pneumonia, urinary tract infections, or sepsis. The AI predicts which antibiotics are likely to work before standard lab results are available. Researchers…

This study follows over 500 hospitalized adults with drug-resistant bacterial pneumonia to see whether those who receive systemic traditional Chinese medicine (such as herbal decoctions or injections) have fewer lower respiratory tract infections in the six months after leaving t…

This early-stage study tests a new pneumococcal vaccine (Pn-MAPS30plus) in 60 healthy infants to see if it is safe and what side effects it may cause. Babies will receive three doses starting around 2 months old, followed by a booster at 12-15 months. The study compares the new v…

This early-phase trial will test a combination of a Chinese herbal formula (Yiqi Huoxue Jiedu) and bacteriophages (viruses that target bacteria) in 250 people with severe pneumonia caused by drug-resistant bacteria. The goal is to see if this combo can clear the infection faster …

This early-phase trial tests a Chinese herbal formula (Yiqi Huoxue Jiedu) combined with bacteriophages—viruses that target specific bacteria—in 240 people with severe pneumonia caused by drug-resistant germs. The goal is to see if the combination clears the infection faster and l…

This study compares two antibiotics—doxycycline and azithromycin—in 208 children aged 3 to 17 with pneumonia caused by Mycoplasma pneumoniae. The goal is to see if doxycycline stops fever faster and is safe, especially regarding tooth color changes. Participants take the medicine…

This early-stage study tests whether adding specially-made viruses (phages) to standard antibiotics can safely treat stubborn lung infections in adults with cystic fibrosis. About 30 participants will receive a 7-day course of both treatments. The main goal is to check safety, bu…

This study tests whether analyzing chemicals in a person's breath can quickly identify serious respiratory infections like COVID-19, flu, and Legionella in hospitalized patients. Researchers will collect breath samples from 777 adults using a simple bag, then analyze them in a la…

This study aims to see if analyzing chemicals in a person's breath can rapidly detect respiratory infections like COVID-19 or the flu. Researchers will collect breath samples from 1,665 adults with symptoms and healthy volunteers. If successful, this non-invasive test could offer…

This study tests whether a rapid PCR test done right in the clinic can help doctors diagnose and treat acute respiratory infections faster. Over 16,000 adults at risk of severe illness will take part. The goal is to see if this approach lowers rates of respiratory failure and hos…

This trial tests whether giving children a probiotic called Saccharomyces boulardii alongside a common antibiotic can prevent diarrhea, a frequent side effect. Children aged 6 months to 5 years with upper respiratory infections will receive either the antibiotic alone or the anti…

This study tests whether a ketogenic diet (low carb, high fat) is better than a standard diet at preserving muscle function in older adults hospitalized with pneumonia. Researchers will enroll 30 patients aged 55 and older and measure handgrip strength and diet adherence. The goa…

This study looks at how well and how safely SIROPSEDAL syrup works for acute cough caused by colds or upper respiratory infections. About 124 children and adults will take the syrup as prescribed by their doctor and report their cough severity over one week. The main goal is to s…

This study looks at whether a fast, bedside test (SPOTFIRE) can help doctors better treat children with respiratory infections in the emergency department. About 720 children aged 2 months to 18 years will be randomly assigned to either get the rapid test or standard care. The go…

Researchers are following about 1,200 children in Zhejiang Province, China, from birth through age 7 to understand how the immune system develops and why some children get more respiratory infections or asthma. The study includes healthy children, children with a history of serio…

This observational study looks at whether children aged 3 months to 16 years are more likely to complete their full course of antibiotics when prescribed at a primary care clinic versus a hospital emergency department. Researchers surveyed parents by phone after treatment ended t…

This study looks at whether the standard dose of the antibiotic ceftazidime-avibactam reaches high enough levels in the blood of people with blood cancers or those who have had a stem cell transplant. These patients are at high risk for severe infections from drug-resistant bacte…

This study investigates whether a particularly dangerous strain of Klebsiella pneumoniae bacteria (hvKP) raises the risk of lung injury in adults with sepsis, compared to a more common strain. Researchers will analyze blood samples for tiny bacterial particles and markers of a sp…

This study examines data from up to 70,000 patients hospitalized with respiratory tract infections in Dutch hospitals between 2018 and 2026. Researchers will analyze how long patients stay, how many need intensive care, and the overall costs. The goal is to help improve hospital …

This study looks at 200 people with pneumonia to find out how many actually have an infection caused by Chlamydia pneumoniae, a type of bacteria. Researchers will use PCR tests to check for the germ and compare results with standard care. The goal is to see if this infection is o…

This study looks at vitamin D levels in 63 critically ill children (ages 1 month to 12 years) admitted to the ICU with severe breathing infections. Researchers will measure vitamin D in the first 24 hours and compare it to how severe the infection is and the risk of death. The go…

This study aims to find out how often multi-drug resistant Klebsiella pneumoniae bacteria carry genes that help them form biofilms (sticky layers) and pump out antibiotics. Researchers will collect urine, pus, and sputum samples from 100 hospital patients with these infections. T…

This study looks at whether certain genes in a dangerous superbug (carbapenem-resistant hypervirulent Klebsiella pneumoniae) make it resistant to the powerful antibiotic cefiderocol. Researchers will collect samples from 100 infected patients and test the bacteria in the lab. The…

This study looks at how different features of an AI system affect the way primary care doctors diagnose and treat respiratory infections. About 3,000 doctors in China will use a web-based tool with various AI features, such as automated data entry or stepwise medication suggestio…

This study will examine gut bacteria, immune markers, and nutrient levels in 120 children with different respiratory health conditions, including pneumonia and recurrent infections, compared to healthy kids. By analyzing stool samples and health data, researchers hope to understa…

This study looks at how the immune system works in people with lung diseases like asthma, COPD, pneumonia, and tuberculosis. Researchers will take a single blood sample from 100 adults to study immune cell changes during inflammation and infection. Participants won't receive dire…

This study will test the antibiotic combination ceftazidime-avibactam on 100 patients with healthcare-associated infections caused by carbapenem-resistant Klebsiella pneumoniae. Researchers will collect samples from blood, urine, and other sites to identify the bacteria and check…

This study will observe 300 children and young adults (ages 0-20) with respiratory tract infections to see if chest ultrasound can predict their outcomes, such as need for hospitalization or ICU care. Researchers will use an ultrasound score and combine it with clinical data to s…