Arteriovenous malformations of the brain

This study tests whether sirolimus, a drug used to prevent organ rejection, can shrink severe arteriovenous malformations (AVMs) and ease symptoms. About 50 people aged 2 and older with advanced AVMs will take the drug for a year. The goal is to see if the drug reduces AVM size b…

This phase 2 trial is testing two targeted drugs—alpelisib and mirdametinib—in 50 people with slow-flow or fast-flow vascular malformations that haven't responded to standard treatments. The goal is to see if these drugs can improve each person's most bothersome symptom over 48 w…

This study looks at how well the PHIL Embolic System works to treat a rare brain condition in children called dural arteriovenous fistulas (DAVFs), where blood vessels connect abnormally. About 15 children under 22 will receive the treatment, which uses a special material to bloc…

This study tests whether the drug bevacizumab, given through a vein, can improve symptoms like headaches, seizures, and thinking problems in people with brain arteriovenous malformations (AVMs) that are too large or risky for surgery or radiation. About 54 adults with moderate to…

This study tests a new liquid embolic agent to treat brain arteriovenous malformations (AVMs), which are tangles of abnormal blood vessels that can cause bleeding or stroke. About 116 adults aged 18 to 80 with certain types of AVMs will receive the treatment and be followed for o…

Brain arteriovenous malformations (bAVMs) are tangles of abnormal blood vessels that can rupture and cause bleeding in the brain. Researchers have found that these malformations often carry specific genetic mutations, but detecting them currently requires analyzing tissue removed…

This Phase 2 trial tests a new type of radiation therapy designed to avoid key brain areas involved in memory and thinking. Sixty adults with 1 to 3 small brain metastases will receive cognitive-sparing stereotactic radiosurgery. The main goal is to see if this approach better pr…

This study creates a large registry of people diagnosed with hereditary hemorrhagic telangiectasia (HHT), a condition causing abnormal blood vessels and bleeding. Researchers will collect medical records and annual health updates for up to 10 years to understand how the disease c…

This study will follow 10 adults with unruptured brain arteriovenous malformations (AVMs) who are scheduled for surgery. Researchers will use special brain scans to measure blood flow and energy use in different brain regions before and six months after the operation. The goal is…

This study aims to make brain aneurysm and AVM treatments safer and more effective by using computer models and artificial intelligence. Researchers will create detailed maps of each patient's brain blood vessels and simulate blood flow to help doctors plan procedures. The study …

This study is gathering information from 4500 people who have or will have brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find patterns that help doctors predict how well someone will recover. By standardizing how outcomes a…

This study follows 400 pregnant women with rare blood vessel diseases (like HHT, Marfan syndrome, or lymphedema) to learn about serious pregnancy complications. Researchers will ask participants about their health during pregnancy and for 12 months after birth. The goal is to gat…

This study follows 1000 adults who have had embolization for brain arteriovenous malformations (AVMs). The goal is to collect standardized long-term data, such as how well the AVM remains blocked over time. Currently, follow-up practices vary widely, so this research aims to impr…

This study looks at the genes of 300 people with brain or spinal cord arteriovenous malformations (AVMs) to see if certain mutations affect the risk of bleeding. Researchers will compare genetic information with medical outcomes to better understand why some AVMs cause serious pr…

This study is collecting information from up to 10,000 people who receive BALT medical devices for conditions like brain aneurysms, stroke, and blocked arteries. Researchers will track how well the devices work and if any safety issues arise during routine care. The goal is to ga…