Aortic aneurysm

This trial tests whether the anesthetic remimazolam keeps blood pressure more stable than the standard drug propofol in adults undergoing surgery to repair an aortic aneurysm. Maintaining steady blood pressure during these procedures helps protect vital organs. Researchers will m…

This study looks at different methods to restore blood flow to the left subclavian artery when it must be covered during aortic repair. Covering this artery can raise the risk of stroke and arm problems. The trial compares surgical bypass with newer endovascular techniques to see…

This study tracks the safety and effectiveness of a stent graft device used to treat aneurysms, dissections, or trauma in the aortic arch (the curved part of the main artery from the heart). Researchers will follow 75 patients in Japan who receive the device, monitoring for compl…

This pilot study tests whether a three-week inpatient cardiovascular rehabilitation program, started three months after abdominal aortic aneurysm repair, improves cardiorespiratory fitness more than standard post-operative care. Researchers will measure changes in maximal oxygen …

This study tests whether a short, controlled clamping of the aorta before aneurysm surgery can prevent acute kidney injury. About 206 patients will be randomly assigned to receive this preconditioning or standard care. The goal is to see if this simple procedure lowers the risk o…

This study tests whether a smartphone app powered by artificial intelligence can help adults recover after heart surgery. 500 patients will either use the app plus standard care or standard care alone. The app gives personalized advice on medications, spotting complications early…

This study tests a 'Fast-Track' approach for repairing abdominal aortic aneurysms using local anesthesia, small incisions, and avoiding the ICU. The goal is to see if patients can safely go home in less than 48 hours, reducing hospital costs and freeing up beds. About 50 people w…

This study tests whether taking aspirin after a minimally invasive aortic arch repair can prevent strokes, a common complication. 224 patients will be randomly assigned to take aspirin for 3, 6, or 12 months. The researchers will track stroke rates, bleeding risks, and other outc…

This study tests a new stent graft device in 100 people with a bulging iliac artery (aneurysm). The device is placed inside the artery to support it and prevent rupture. Researchers will track serious complications like stroke, heart attack, or kidney problems over time to see if…

This study is testing three types of Bentley stent grafts used to repair complex abdominal aortic aneurysms. Researchers will follow 150 adults for 12 months to see how well the grafts work and if there are any side effects. The goal is to improve the safety and success of this m…

This study tests whether giving dry plasma to people with massive bleeding before they reach the hospital can improve survival. Researchers will compare dry plasma to standard fluids in 650 adults with signs of bleeding shock. The main goal is to see if more people survive the fi…

This study tests a special silver-coated mesh placed during emergency abdominal surgery to see if it can prevent surgical site infections and incisional hernias. About 110 adults having urgent open abdominal surgery will take part. Researchers will track infection and hernia rate…

This study tests whether placing soft foam dressings on the skin before heart surgery can prevent pressure injuries (bedsores). About 80 adults having long heart surgeries will be enrolled. Researchers will check for new skin injuries after surgery and track how severe they are. …

This study tests whether giving steroids before a major aortic repair surgery (TEVAR) can prevent postimplantation syndrome—a flu-like inflammatory reaction that often leads to longer hospital stays and serious heart problems. About 174 adults scheduled for elective aortic repair…

Aortic arch surgery temporarily cuts blood flow to the brain, which can leave patients with lasting thinking and memory problems. Researchers at Seoul National University Hospital are testing whether anesthesia with remimazolam, rather than propofol, lowers the chance of that cog…

This trial tests whether a 6-week prehabilitation program called Ready for Recovery can help adults prepare for aortic aneurysm repair surgery. The program includes education, health behavior support, psychological symptom reduction, and social support, with weekly phone sessions…

This study tracks discomfort in 132 people who had endovascular repair for aortic dissection. It measures pain, skin issues, stress, and self-care problems. Some patients will receive extra education after surgery to see if it reduces these symptoms.

This study is testing whether a deep-learning computer model can predict, from a CT scan taken before surgery, which patients will develop a type II endoleak and aneurysm enlargement after endovascular aneurysm repair (EVAR). The model is being developed using data from multiple …

This study will create a computer tool to predict which older adults are at high risk for serious problems after heart or blood vessel surgery. It will also test if special programs before and during surgery can help prevent confusion, heart issues, and death. About 1,200 people …

This study tests whether ultrasound of the optic nerve sheath, a marker of brain pressure, can track brain swelling during ascending aortic surgery. Researchers will measure the optic nerve sheath diameter before, during, and after surgery in 134 adults undergoing this procedure.…

This study explores whether ultrasound can reliably measure aneurysms in the descending thoracic aorta, the part of the main artery that runs through the chest. Researchers will compare ultrasound measurements with standard CT scans in about 60 adults, including some with known a…

This study looks back at medical records of about 350 people who had a specific stent graft placed during a complex aortic surgery called a frozen elephant trunk procedure, used to treat aortic aneurysms or dissections. The goal is to see how often major complications like stroke…

This study will use a special scan to look for B cells (a type of immune cell) in the blood vessels of 30 people with giant cell arteritis, a serious disease that can cause blindness or stroke. Current treatments rely on steroids, which have harsh side effects. If the scan works,…

This registry will follow 400 people with complex aortic aneurysms who are treated with GORE devices that help keep blood flowing to vital organs. The goal is to see how well the devices work and how safe they are in everyday medical practice. Participants must need at least one …

This study tests whether evolocumab, a drug that lowers 'bad' cholesterol, changes the cells in the wall of an abdominal aortic aneurysm. About 44 people scheduled for aneurysm repair will receive either the drug or a placebo before surgery. Researchers will then compare the tiss…

This study will look at 800 patients who had aortic surgery to understand why some develop dangerous blood clots inside the repaired artery. Researchers want to find out how common these clots are, what puts patients at risk, and how they affect recovery. The goal is to improve c…

This study will use special CT scans that track both the heartbeat and breathing to see how a stent graft moves inside the abdominal aorta after aneurysm repair. Twenty-five patients with complex aneurysms will be scanned before surgery, at discharge, and at 6 and 12 months after…

This study will collect data from 1100 people with peripheral artery disease or abdominal aortic aneurysm across six European centers. Researchers will use artificial intelligence to analyze clinical data, blood samples, imaging, and wearable device information to build tools tha…