Promising drug combo targets tough bone cancer

NCT ID NCT04067115

First seen Jan 05, 2026 · Last updated May 14, 2026 · Updated 19 times

Summary

This study tested a combination of two drugs, trabectedin and irinotecan, in 37 people with a type of bone cancer called Ewing sarcoma that had come back or not responded to other treatments. The goal was to find the safest dose and see if the drugs could shrink tumors. Participants also received a special PET scan to help track how well the treatment was working.

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Contacts and locations

Locations

  • Boston Children's Hospital / Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Children's Hospital of Los Angeles

    Los Angeles, California, 90027, United States

  • Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • National Cancer Institute

    Bethesda, Maryland, 20892, United States

  • University of Michigan

    Ann Arbor, Michigan, 48106, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19105, United States

Conditions

Explore the condition pages connected to this study.