Can a better antidote stop opioid overdoses faster?
NCT ID NCT05338632
First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time
Summary
This study investigates how effectively two opioid antidotes—naloxone (given as a nasal spray or injection) and nalmefene (given as an injection)—can reverse dangerous breathing problems caused by strong opioids like fentanyl. The trial includes both healthy volunteers and people who use opioids regularly, aiming to find the best doses for real-life overdose situations.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- naloxone and nalmefene (opioid antagonists)
- What this could lead to
- If successful, this could lead to better dosing guidelines for reversing opioid overdoses, potentially saving more lives.
- What could go wrong
- This is an early-phase study with a small number of participants, so results may not apply to all real-world overdose situations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Leiden University Medical Center
Leiden, South Holland, 2333 ZA, Netherlands
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