New scan could spot hidden stroke risk in blocked arteries

NCT ID NCT05838547

Recruiting now Knowledge-focused Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a new type of PET-MR scan can help predict stroke risk in people with significant narrowing of the carotid artery (the main artery in the neck) who have not yet had symptoms. Researchers will give participants an injection of a radioactive tracer and take images of their arteries. They will then follow participants for up to 18 months to see who has a stroke or needs treatment, to see if the scan signal correlates with risk.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 64Cu-25%-CANF-Comb (a radioactive tracer for PET imaging)
What this could lead to: If successful, this could lead to a better way to identify which patients with carotid artery narrowing are at highest risk for stroke, helping guide treatment decisions.
What could go wrong: This is an early observational study, not a treatment trial. The imaging technique may not prove accurate enough to predict risk, and results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder carotid artery disorder carotid stenosis stroke disorder vascular disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASYMPTOMATIC CAROTID ARTERY STENOSIS CAROTID ARTERY ATHEROMA CAROTID ATHEROSCLEROSIS

Contacts and locations

Locations

Cedars Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Washington University in St. Louis
RECRUITING

St Louis, Missouri, 63130-2344, United States

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