Targeted drug tested for tough cancers with rare genetic flaw

NCT ID NCT05169437

Terminated Disease control Sponsor: Tempus AI Source: ClinicalTrials.gov ↗

Summary

This study tested whether the drug niraparib could help control advanced solid tumors in patients whose cancer has a specific genetic change called a PALB2 mutation. It involved 22 adults with various cancers (like breast, lung, or pancreatic) that had spread or were locally advanced and who had few other treatment options. The main goal was to see if the tumor shrank or stopped growing and to monitor the drug's safety.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Aultman Medical Group

Canton, Ohio, 44708, United States
Avera Cancer Institute

Sioux Falls, South Dakota, 57105, United States
Baptist Cancer Center

Memphis, Tennessee, 38120, United States
Beacon Health System

South Bend, Indiana, 46601, United States
Bon Secours - St. Francis Cancer Center

Greenville, South Carolina, 29607, United States
Cancer Specialists of North Florida

Jacksonville, Florida, 32256, United States
Cancer and Blood Specialty

Los Alamitos, California, 90720, United States
Cancer and Blood Specialty Clinic

Los Alamitos, California, 90720, United States
Central Care Cancer Center

Bolivar, Missouri, 65613, United States
Cleveland Clinic - Taussig Cancer Center

Cleveland, Ohio, 44195, United States
Community Cancer Trials of Utah

Ogden, Utah, 84405, United States
Community Health Network

Indianapolis, Indiana, 46250, United States
Eastern Connecticut Hematology and Oncology

Norwich, Connecticut, 06360, United States
Englewood Health

Englewood, New Jersey, 07631, United States
Fort Wayne Medical Oncology and Hematology

Fort Wayne, Indiana, 46845, United States
Frederick Health

Frederick, Maryland, 21702, United States
Gettysburg Cancer Center

Gettysburg, Pennsylvania, 17325, United States
Goshen Health

Goshen, Indiana, 46526, United States
Hartford Healthcare

Hartford, Connecticut, 06102, United States
Hawaii Cancer Care

Honolulu, Hawaii, 96813, United States
Hematology Oncology Associates of Fredericksburg

Fredericksburg, Virginia, 22408, United States
Highlands Oncology

Springdale, Arkansas, 72762, United States
Holy Cross

Fort Lauderdale, Florida, 33308, United States
Inova Schar Institute

Fairfax, Virginia, 22031, United States
Lumi Research

Sugar Land, Texas, 77479, United States
Mary Crowley Cancer Research

Dallas, Texas, 75230, United States
Maryland Oncology Hematology

Rockville, Maryland, 20850, United States
Memorial Care Medical Center

Fountain Valley, California, 92708, United States
MemorialCare

Long Beach, California, 90806, United States
Mosaic Life Care

Saint Joseph, Missouri, 64507, United States
Nebraska Cancer Specialists

Omaha, Nebraska, 68130, United States
New Jersey Cancer Care and Blood Disorders

Belleville, New Jersey, 07109, United States
Northwest Medical Specialties

Tacoma, Washington, 98405, United States
Northwest Oncology & Hematology

Rolling Meadows, Illinois, 60008, United States
Novant Health Inc. - Charlotte

Charlotte, North Carolina, 28204, United States
Novant Health Inc. - Winston-Salem

Winston-Salem, North Carolina, 27103, United States
Ocala Community Cancer Center

Ocala, Florida, 34474, United States
OhioHealth

Columbus, Ohio, 43214, United States
Oklahoma Cancer Specialists

Tulsa, Oklahoma, 74146, United States
Oncology Consultants

Houston, Texas, 77030, United States
Oncology Hematology Associates

Springfield, Missouri, 65807, United States
OptumCare Cancer Care

Las Vegas, Nevada, 89102, United States
Oregon Oncology Specialists

Salem, Oregon, 97301, United States
PeaceHealth

Bellingham, Washington, 98225, United States
Pontchartrain Cancer Center

Hammond, Louisiana, 70403, United States
Ridley-Tree Cancer Center

Santa Barbara, California, 93105, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
SSM Health

Madison, Wisconsin, 53717, United States
Sanford Health

Sioux Falls, South Dakota, 57117, United States
Sharp Healthcare

San Diego, California, 92123, United States
Southcoast Health

Fairhaven, Massachusetts, 02719, United States
Southeastern Medical Oncology Center

Goldsboro, North Carolina, 27534, United States
Sparrow Health

Lansing, Michigan, 48912, United States
St Joseph Health Medical Group - Napa

Napa, California, 94558, United States
St Joseph Health Medical Group - Santa Rosa

Santa Rosa, California, 95403, United States
St Joseph Heritage Health - Fullerton

Fullerton, California, 92835, United States
Summit Medical Group

Florham Park, New Jersey, 07932, United States
Texas Oncology - Austin Central Pharmacy

Austin, Texas, 78731, United States
Texas Oncology - Austin Midtown

Austin, Texas, 78705, United States
Texas Oncology - Baylor Charles A. Sammons Cancer Center

Dallas, Texas, 75246, United States
Texas Oncology - Longview Cancer Center

Longview, Texas, 75601, United States
Texas Oncology - Palestine Cancer Center

Palestine, Texas, 75801, United States
Texas Oncology - Paris Cancer Center

Paris, Texas, 75460, United States
Texas Oncology - South Austin

Austin, Texas, 78745, United States
Texas Oncology - Tyler Pharmacy

Tyler, Texas, 75702, United States
The Center for Cancer and Blood Disorders - Maryland

Bethesda, Maryland, 20817, United States
The Toledo Clinic

Toledo, Ohio, 43623, United States
The University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
ThedaCare

Appleton, Wisconsin, 54911, United States
TriHealth

Cincinnati, Ohio, 45220, United States
University Cancer & Blood Center

Athens, Georgia, 30607, United States
University Hospitals Seidman

Cleveland, Ohio, 44106, United States
University of California Los Angeles

Los Angeles, California, 90404, United States
University of California San Diego

La Jolla, California, 92093-0698, United States
Utah Cancer Specialists

Salt Lake City, Utah, 84106, United States
Vanderbilt University

Nashville, Tennessee, 37232, United States
Ventura County Hematology Oncology Specialists

Oxnard, California, 93030, United States
Virginia Cancer Institute

Richmond, Virginia, 23229, United States
Virginia Cancer Institute

Richmond, Virginia, 23230, United States
Yuma Regional Medical Center

Yuma, Arizona, 85364, United States

Conditions

Explore the condition pages connected to this study.

BREAST TUMOR COLON TUMOR, MALIGNANT ENDOMETRIAL CANCER ESOPHAGEAL CANCER HEAD AND NECK CANCER LOCALLY ADVANCED SOLID TUMOR LUNG TUMOR MELANOMA METASTATIC CANCER PANCREATIC CANCER SOLID TUMOR UROLOGIC CANCER