New breathing mode tested in tiny infants with severe lung condition

NCT ID NCT04821453

Terminated Symptom relief Sponsor: Children's Hospital of Philadelphia Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested two different ways of using a breathing machine (ventilator) in 12 premature infants with severe bronchopulmonary dysplasia (BPD), a serious lung condition. One mode, called NAVA, uses the baby's own diaphragm signals to trigger breaths, while the other, CMV, uses airflow. The goal was to see if NAVA improves oxygen levels and reduces the need for sedation. The trial was stopped early, so results are limited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Neurally Adjusted Ventilatory Assist (NAVA) mode of mechanical ventilation
What this could lead to: If successful, this could show that NAVA is a better way to support breathing in infants with severe lung disease, potentially improving oxygen levels and reducing stress.
What could go wrong: This was a very small pilot study (12 infants) that was terminated early, so results are limited. It may not show a clear benefit over standard ventilation.

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Conditions

The condition(s) this trial relates to.

bronchopulmonary dysplasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRONCHOPULMONARY DYSPLASIA MECHANICAL VENTILATION NEURALLY ADJUSTED VENTILATORY ASSIST

Contacts and locations

Locations

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Rhode Island Hospital (Hasboro Children's Hospital)

Providence, Rhode Island, 02903, United States

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