New breathing mode tested in tiny infants with severe lung condition
NCT ID NCT04821453
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested two different ways of using a breathing machine (ventilator) in 12 premature infants with severe bronchopulmonary dysplasia (BPD), a serious lung condition. One mode, called NAVA, uses the baby's own diaphragm signals to trigger breaths, while the other, CMV, uses airflow. The goal was to see if NAVA improves oxygen levels and reduces the need for sedation. The trial was stopped early, so results are limited.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Neurally Adjusted Ventilatory Assist (NAVA) mode of mechanical ventilation
What this could lead to
If successful, this could show that NAVA is a better way to support breathing in infants with severe lung disease, potentially improving oxygen levels and reducing stress.
What could go wrong
This was a very small pilot study (12 infants) that was terminated early, so results are limited. It may not show a clear benefit over standard ventilation.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Rhode Island Hospital (Hasboro Children's Hospital)
Providence, Rhode Island, 02903, United States