Gene study may explain why some breast cancers resist hormone therapy
NCT ID NCT05183828
First seen Jan 26, 2026 · Last updated Jun 12, 2026 · Updated 21 times
Summary
This study looked at whether a specific gene mutation (HSD3B1) changes how well the hormone therapy letrozole works in postmenopausal women with early-stage, hormone-sensitive breast cancer. Researchers measured changes in tumor markers before and after treatment. The trial was ended early, but the goal was to learn why some cancers don't respond well to standard hormone therapy.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Fred Hutch/University of Washington Cancer Consortium
Seattle, Washington, 98109, United States
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