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Can a diuretic plan clear excess fluid in critically ill patients?

NCT ID NCT02345681

Disease control Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Critically ill patients in the intensive care unit often accumulate too much fluid, which can lead to complications. This trial tests whether a furosemide-based algorithm can safely reduce fluid overload in patients who are on mechanical ventilation and have gained at least 3% of their body weight. Researchers will compare fluid balance and outcomes like ventilator-free days and ICU stay between patients who receive the algorithm and those who do not.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
furosemide, a diuretic that helps the body remove excess fluid
What this could lead to
If it works, this could give ICU doctors a clear, step-by-step way to use diuretics to reduce fluid buildup, potentially shortening time on a ventilator and stay in intensive care.
What could go wrong
Diuretics can cause dehydration, kidney problems, or low blood pressure, especially in very sick patients. The trial is small and early, so the approach may not work or may not be safe for all ICU patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

171 people

The number who actually took part.

Started

May 2015

Finished

Apr 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age of 18 or more * Patients receiving endo-tracheal intubation and mechanical ventilation during their stay in the ICU * Weight increase of at least 3 % during the stay. Baseline weight is regarded as the weight at the 24th hour after ICU admission * FiO2 \< 60 %, PEEP \< 10cmH20 * No administration of catecholamines other than dobutamine at a dose of 10 microg.Kg-1.min-1 Exclusion Criteria: * Pregnancy * Patient with a moribund state at ICU arrival * Acute brain injury (traumatic brain injury, subarachnoid hemorrhage, intra-cerebral bleeding, stroke, meningo-encephalitis, coma from medication origin) * Chronic kidney disease defined as creatinin clearance \< 30mL.min-1 and/or with chronic dialysis * Mandatory administration of diuretics (cardiogenic pulmonary oedema, LVEF \< 30 %)

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Conditions

The condition(s) this trial relates to.

Edema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fluid balance of icu patients Fluid overload

Contacts and locations

Locations

  • CHD Vendée

    La Roche-sur-Yon, France

  • CHU de Nantes

    Nantes, 44093, France

  • Hôpital François Mitterand

    Dijon, France

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