CT scans could help tailor ventilator settings for sepsis patients

NCT ID NCT05977153

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looks at two ways of setting a breathing machine (ventilator) for people with sepsis who need help breathing. One method is personalized based on each patient's lung measurements, while the other is a standard approach. Researchers will use CT scans to see how air moves in the lungs and compare which method causes less strain. The goal is to find better ways to protect the lungs during mechanical ventilation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
personalized ventilator settings (PEEP adjustment)
What this could lead to
If successful, this could help doctors choose better ventilator settings for sepsis patients, potentially reducing lung damage.
What could go wrong
This is a very small, early-phase study with only 7 participants, so results may not apply broadly. It focuses on imaging markers, not direct patient outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute lung injury infectious disease with sepsis Systemic Inflammatory Response Syndrome Ventilator-Induced Lung Injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Columbia University

    New York, New York, 10025, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.