Heart surgery patients may get brain protection from common sedative

NCT ID NCT04289142

First seen Jan 10, 2026 · Last updated May 03, 2026 · Updated 17 times

Summary

This study tests whether a sedative called dexmedetomidine can prevent long-term memory and thinking problems that often occur after heart surgery. About 2,400 adults aged 60 and older having bypass or valve surgery will receive either dexmedetomidine or a placebo during their operation. Researchers will track their cognitive function for up to a year to see if the drug helps protect the brain.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Laval University

    RECRUITING

    Québec, Quebec, G1V 0A6, Canada

    Contact

    Contact Email: •••••@•••••

  • London Health Sciences

    ACTIVE_NOT_RECRUITING

    London, Ontario, N6A 5A5, Canada

  • Royal Columbian Hospital

    ACTIVE_NOT_RECRUITING

    Vancouver, British Columbia, V3L 0A2, Canada

  • St. Michael's Hospital

    NOT_YET_RECRUITING

    Toronto, Ontario, M5B 1W8, Canada

    Contact

    Contact Email: •••••@•••••

  • St. Paul's Hospital

    RECRUITING

    Vancouver, British Columbia, V6Z 1Y6, Canada

    Contact Email: •••••@•••••

    Contact

  • Sunnybrook Health Sciences Centre

    RECRUITING

    Toronto, Ontario, M4N 3M5, Canada

    Contact

    Contact

    Contact

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact

    Contact

    Contact

    Contact

  • Toronto General Hospital

    ACTIVE_NOT_RECRUITING

    Toronto, Ontario, M5G 2C4, Canada

  • University of Saskatchewan

    ACTIVE_NOT_RECRUITING

    Saskatoon, Saskatchewan, S7N 0W8, Canada

Conditions

Explore the condition pages connected to this study.