Can DNA predict transplant trouble in kids?

NCT ID NCT07194057

Not yet recruiting Knowledge-focused Sponsor: Instituto de Investigación Hospital Universitario La Paz Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study will analyze the DNA and chemical marks on DNA of 200 children who have had a liver or kidney transplant. Researchers want to find genetic clues that might explain why some children develop serious complications like organ rejection, infections, or cancer after transplant. No extra procedures are needed—samples are taken during routine care. The goal is to better predict and manage these risks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Whole genome sequencing and methylation analysis
What this could lead to: If successful, this could help doctors predict and prevent complications after a child's organ transplant, improving long-term outcomes.
What could go wrong: This is an observational study, not a treatment trial. It is small (200 children) and early, so findings may not apply to all transplant patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

disease related to transplantation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY TRANSPLANT LIVER TRANSPLANT TRANSPLANT COMPLICATION

Contacts and locations

Locations

Hospital Universitario La Paz

Madrid, Madrid, 28046, Spain
Mediterranean Institute for Transplantation (ISMETT)

Palermo, Sicily, 90127, Italy
University Hospital Padova

Padova, 35128, Italy
University Medical Center Hamburg-Eppendorf (UKE),

Hamburg, 20251, Germany

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