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Serial multiomics profiling using serum and cerebrospinal fluid samples following out-of-hospital cardiac arrest: a prospective observational study

NCT ID NCT07090577

NEW Sponsor: Chungnam National University Hospital Source: ClinicalTrials.gov ↗

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Recruiting now
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Not yet recruiting
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Completed
The trial has finished. Results may not be published yet.
Stopped early
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Cancelled
Cancelled before anyone took part.

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Approved
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First seen Sep 10, 2026 · Last updated Sep 10, 2026

Summary

The goal of this observational study is to identify further pathophysiologic mechanism of secondary brain injury following cardiac arrest by using serial multiomics profiling of serum and cerebrospinal fluid (CSF) samples. The main question it aims to answer is: A. The main question it aims to answer is: What are the dynamic molecular changes in serum and CSF that reflect the pathophysiological mechanisms of secondary brain injury after cardiac arrest? B. What are the differences in serum and CSF multiomic signatures between varying severities of cardiac arrest, and how are these differences associated with the underlying pathophysiological mechanisms of secondary brain injury? Serum and CSF samples that have already been prospectively collected from participants and stored in the BioBank will be used for this analysis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

15 people

The number who actually took part.

Started

Jul 2025

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients with an out-of-hospital cardiac arrest who underwent post-resuscitation care

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years old * Out-of-hospital cardiac arrest (OHCA) * Patients who have received post-resuscitation care including temperature control due to unconsciousness (Glasgow Coma Score \< 8) after sustained ROSC. * Patients who consented to the placement of lumbar catheter for storing cerebrospinal fluid and blood samples in a human biobank. Exclusion Criteria: * Patients diagnosed with a central nervous system-related disease before cardiac arrest * Patients who have undergone extracorporeal circulatory membrane oxygenation therapy * Patients who died within 24 hours from post-resuscitation care

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Conditions

The condition(s) this trial relates to.

brain hypoxia - ischemia cardiac arrest

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac arrest (CA) Hypoxic-ischemic brain injury Post-resuscitation syndrome

Contacts and locations

Locations

  • Chungnam National University Hospital

    Daejeon, 35015, South Korea

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