Can zapping the brain slow language decline? new trial investigates

NCT ID NCT07158216

Recruiting now Symptom relief Sponsor: Hospital San Carlos, Madrid Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether two types of non-invasive brain stimulation—TMS and tDCS—can slow language decline in people with primary progressive aphasia, a condition that gradually impairs speech and understanding. Over 6 months, 80 participants will receive either real or sham stimulation along with language therapy. The goal is to see if these brain-zapping techniques can help preserve communication skills longer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS)
What this could lead to: If successful, this could point toward a non-drug way to help people with primary progressive aphasia maintain language skills longer.
What could go wrong: This is an early-stage trial with only 80 participants, so results may not apply to everyone. The benefits might be small or temporary, and the stimulation can cause mild discomfort or headache.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

frontotemporal dementia primary progressive aphasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRIMARY PROGRESSIVE APHASIA(PPA)

Contacts and locations

Locations

Hospital Clinico San Carlos
RECRUITING

Madrid, Spain

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