University Of Zurich

This study tests a weekly, image-guided radiation therapy (SBRT) for men with very high-risk prostate cancer that may have spread to nearby lymph nodes. The treatment uses weekly CT or MRI scans to adapt the radiation dose precisely to the tumor. The main goals are to see if this…

This study explores whether a PET/MR scan using a radioactive tracer called 18F-Florbetaben can detect amyloid deposits—abnormal protein clumps that can damage organs—in people with certain blood disorders. Participants receive a single injection of the tracer followed by a whole…

This study tests whether a new MRI contrast agent, gadopiclenol, can detect brain metastases earlier than standard methods in 180 patients with advanced lung, breast, or skin cancer. Participants will receive screening brain MRIs to compare diagnosis timing and accuracy. The goal…

This study tests if a new flexible cable (SuperCable) is better than standard steel wire for closing the breastbone after heart surgery. About 86 adults will be randomly assigned to one method. The goal is to see if SuperCable leads to faster bone healing, less pain, and shorter …

This study looks at whether a special low-field MRI scanner can give clearer images for prostate cancer radiation therapy in people who have both hips replaced. Standard MRI often creates blurry images around metal implants, making it hard to aim the radiation precisely. The rese…

This study looks at how exercise affects a natural cell cleanup process called autophagy, which may be linked to depression. Researchers will have 120 healthy adults do a cycling test and take blood samples to measure changes in autophagy and related genes. The goal is to better …

This study looks at whether breathing extra oxygen can improve thinking and reaction time in healthy people who live at high altitude (about 2500 meters). Fifty Kyrgyz adults will receive both real oxygen and a sham treatment to compare. The goal is to see if mental changes cause…

This study tests a lab technique called pharmacoscopy that analyzes a patient's tumor tissue to find which drugs might work best for them. It includes 40 adults with various aggressive or rare brain tumors that have not responded to standard treatments. The main goal is to see if…

This study looks at how satisfied young people and those with low incomes are with free HIV and STI testing and counselling in Lucerne and Zurich. Around 1,800 participants will fill out a questionnaire after their visit. The goal is to see if these free services meet people's ne…

This study looks at how different ways of processing soy (like heating or fermenting) change its ability to cause allergic reactions. Researchers will test processed soy in the lab and then on the skin of 55 adults with soy allergy. The goal is to understand which processing meth…

This study looks at a new way to assess pain in intensive care patients who are on breathing machines and cannot speak. It uses a special tool (AlgiScan) and a behavioral checklist to adjust pain medicine more safely. Researchers will compare data from 400 adults to see if the ne…

This pilot study tests whether fecal microbiota transplantation (FMT) can change the gut microbiome in 30 people with type 2 diabetes and stable coronary artery disease. Participants receive processed stool from healthy donors via colonoscopy. The goal is to see if this alters gu…

This study aims to better understand heart failure by deeply analyzing the genes, proteins, and other molecules in patients' blood and tissues. Researchers will enroll 500 adults with heart failure and combine detailed clinical data with advanced lab tests. The goal is to find mo…

This study looks at how age and sex influence the body's ability to manage phosphate after a single oral dose. Forty healthy volunteers in two age groups (18-25 and 63-70) will ingest 558 mg of phosphorus, and researchers will measure phosphate levels in the blood over time. The …