University Of Southern California

This study tests whether the antibiotic linezolid can effectively treat early syphilis in 24 adults. Participants have primary, secondary, or early latent syphilis, and some also have well-controlled HIV. The main goal is to see if linezolid reduces syphilis infection markers in …

This study tests whether adding an experimental drug (PF-04518600) that boosts the immune system to the standard drug axitinib can help control advanced kidney cancer better than axitinib alone. About 62 adults whose cancer has spread and who have already tried an immune checkpoi…

This study aimed to compare different surgical methods for treating receding gums, including flap procedures and tunneling techniques, with or without a platelet-rich fibrin concentrate. It planned to enroll 100 adults with multiple gum recession defects. However, the study was w…

This early-stage trial tests a new version of the chemotherapy drug paclitaxel, called FID-007, in 50 adults with advanced solid tumors that no longer respond to standard treatments. The drug is wrapped in a special polymer to help it reach deeper into tumors while sparing health…

This early-phase study tests a new drug (sEphB4-HSA) combined with standard chemotherapy in people with advanced or metastatic solid tumors, including head and neck, pancreatic, lung, and gallbladder cancers. The goal is to find the best dose and check for side effects. About 61 …

This study looks at whether a simple risk screening and a short caregiver training program can help prevent elder abuse in people with dementia. About 1,000 caregivers will fill out surveys and some will also get the screening or training. The goal is to see if these tools can re…

This study tested a special wound vacuum device on people who had a leg amputation to see if it helps reduce swelling, heal faster, and get patients walking sooner compared to standard bandages. The study was planned for 6-10 adults, but it was withdrawn before any participants e…

This study is testing a new bilingual web tool designed to help people with chronic sinusitis make informed decisions about their treatment, including whether to have surgery. About 50 patients from USC clinics will be randomly assigned to use the tool or receive standard informa…

This study looks at how colorectal cancer affects the physical and emotional well-being of adolescents and young adults (ages 18-39). Researchers will measure symptoms like fatigue, pain, and anxiety, as well as physical fitness, to better understand the challenges these patients…

This study uses a very powerful 7 Tesla MRI scanner to take detailed pictures of the brain in testicular cancer patients who have low testosterone (hypogonadism) and are on testosterone replacement therapy. The goal is to see if the MRI can detect changes in brain structure and f…

This study tests an educational program to train Hispanic/Latino community members about colorectal cancer genetics and genetic testing. The goal is to increase knowledge and confidence so they can share this information with others. About 20 participants will take part in weekly…

This study tests a special camera that measures oxygen levels in the bowel during colorectal surgery. About 52 adults having laparoscopic surgery for colon cancer or diverticulitis will take part. The goal is to see if this imaging can help doctors find areas with poor blood flow…