University College, London

This large phase 3 trial tests whether adding targeted radiotherapy (SABR) or a radioactive drug (PSMA-Lutetium) to standard hormone therapy can slow cancer spread and improve survival in people with metastatic prostate cancer. About 3,360 participants across the UK will be rando…

This study tests whether deep brain stimulation (DBS) can safely reduce seizures in 22 children aged 5-14 with Lennox-Gastaut syndrome, a severe form of epilepsy. The device, called Picostim, is implanted in the brain and delivers electrical pulses. The trial is double-blind and …

This study tests whether giving the immunotherapy drug pembrolizumab before surgery can help people with a specific type of colorectal cancer (called MMR-deficient or MSI-high). The drug helps the immune system fight cancer cells. The goal is to see if this approach is safe, impr…

This study compares two chemotherapy combinations (ABVD and A2VD) for people with early-stage Hodgkin lymphoma that hasn't been treated yet. About 1,042 participants will receive 3-4 cycles of chemo, and a PET scan after 2 cycles helps doctors decide if more treatment is needed. …

This study looks at whether removing only half of the thyroid (hemithyroidectomy) works as well as removing the whole thyroid (total thyroidectomy) for people with low-risk thyroid cancer. About 456 adults with this cancer will be randomly assigned to one of the two surgeries. Th…

This study tests whether using a high-efficiency air filter in the bedroom overnight can lower inflammation (measured by a blood marker called CRP) in adult cancer survivors living in polluted urban areas. Ten participants will each try both filtered and unfiltered air for two-we…

This large clinical trial is testing several potential treatments at once to see if they can slow the progression of Parkinson's disease. About 1,200 people with Parkinson's will take either an experimental drug or a placebo for up to 36 months. The study uses a flexible design t…

This study tests whether proton beam radiation can help people with a rare lung cancer called malignant pleural mesothelioma. About 148 adults whose cancer is only on one side of the chest will receive either proton therapy or standard care. The goal is to see if the treatment de…

This early-phase study tests whether a drug called NIO752 can reduce the brain's production of tau, a protein that forms harmful tangles in Alzheimer's disease. Ten adults with mild to moderate Alzheimer's will receive either the drug or a placebo via spinal injection. The main g…

This early-stage trial tests a new type of CAR T cell therapy for people with multiple myeloma that has come back or not responded to other treatments. The therapy uses specially engineered immune cells to target two proteins (BCMA and CD19) on cancer cells. The main goals are to…

This study tests a smartphone app called neoSCB that screens for jaundice in newborns by taking a photo of the baby's eye. Jaundice is common and usually harmless, but severe cases need treatment to prevent brain damage. The app aims to accurately detect high bilirubin levels wit…

This study compares two types of robotic-arm assisted knee replacements in 120 people with knee osteoarthritis. One uses cement to fix the implant, the other does not. The main goal is to see which approach helps patients feel like their knee is more natural and less like an arti…

This study aims to collect spinal fluid and blood samples from 2,500 volunteers at different stages of Huntington's disease. Researchers will analyze these samples to find biological markers that can help develop new treatments. The study does not test any drug, but instead build…

This study looks at whether two types of bladder function tests (urodynamics and video-urodynamics) help improve surgical results for women with recurrent stress urinary incontinence. Thirty women who have already had unsuccessful incontinence surgery will be randomly assigned to…

This study aims to understand why physical activity helps with depression. Researchers will compare aerobic exercise to stretching in 250 adults with moderate depression. They will measure changes in the brain, immune system, and motivation to find out how exercise works. The goa…

This study is testing a 21-day self-guided digital program to help healthy volunteers prepare for a supervised psilocybin session. Forty people will be randomly assigned to either a meditation or music-listening program. The main goal is to see if the program is practical and eas…