University College, London

This study looks at people who have chest X-ray signs of TB but test negative for the bacteria in their sputum. It tests if shorter treatment (8 to 24 weeks) works as well as the standard 24-week course, and whether close monitoring without immediate treatment is safe. About 784 …

This study tests a new injectable radioactive drug, Actinium-225 rhPSMA-10.1, in 60 men with advanced prostate cancer that has spread and is no longer responding to standard treatments. The drug aims to attach to and destroy cancer cells with radiation. Researchers will find safe…

This study tests whether two common heart failure drugs, dapagliflozin and spironolactone, can help the heart muscle recover more fully after aortic valve replacement. About 445 adults with severe aortic stenosis will take one or both medicines daily for 12 months. The goal is to…

This study tests a new tool called LaserSAFE that uses a special microscope to scan the prostate right after it is removed during surgery. The goal is to see if it can quickly find cancer cells at the edge of the prostate, which helps surgeons decide whether it is safe to spare n…

This study tests a new questionnaire designed to help dentists and doctors identify trigeminal neuralgia, a condition that causes sudden electric-shock-like pain in the face. The pain is often mistaken for a tooth problem, leading to unnecessary dental treatments. About 250 adult…

This pilot study in Zimbabwe tests whether trained young mentor mothers (YMMs) can help pregnant and breastfeeding teens and young women (ages 15-24) use HIV prevention tools like PrEP and contraception. About 600 participants will be split into groups to see if this peer-led app…

This study tests whether an intensive 4-week communication program (100 hours of therapy) can improve quality of life for people with aphasia after a stroke. About 334 adults who had a stroke at least 3 months ago will be randomly assigned to the program or standard care. The mai…

This study aims to understand why some people develop a complication called PVR after surgery for a detached retina. Researchers will collect a small sample of eye fluid during surgery and take special eye images before and after the operation. By analyzing these samples and imag…

This study tests if surgeons can safely add a small step—cauterizing tiny blood vessels—during standard brain drainage surgery for chronic subdural hematoma (a type of brain bleed common in older adults). About 30 adults will take part. The goal is to see if the extra step is fea…

This study tests a new program for young people aged 11-18 who are already getting therapy for emotional issues like anxiety or depression. Half will get extra help from a 'Link Worker' to connect with community activities (e.g., sports, arts, volunteering), while the other half …