Shanghai Ninth People's Hospital Affiliated To Shanghai Jiao Tong University

This trial investigates whether combining two drugs, camrelizumab and famitinib, can help people with rare head and neck cancers that have spread or cannot be removed by surgery. The study includes four types of these cancers and aims to see how safe and effective the treatment i…

This phase 2 trial is testing a special form of the chemotherapy drug paclitaxel, called polymeric micelles, combined with carboplatin in 29 people with recurrent or metastatic head and neck squamous cell carcinoma. The goal is to see how well the treatment shrinks tumors and to …

This phase II trial tests a combination of two drugs, sacituzumab tirumotecan and toripalimab, as a first treatment for recurrent or metastatic head and neck squamous cell carcinoma. The study enrolls 39 adults whose tumors have specific markers (Trop2 and CPS). The goal is to se…

This phase 2 trial tests two drugs, Iparomlimab and Tuvonralimab, in 30 adults with recurrent or metastatic head and neck cancer that has not responded to at least two prior treatments. Participants receive the drugs by IV every 21 days. The main goal is to see if the combination…

This Phase II trial tests whether giving a combination of two drugs—Becotatug Vedotin (a targeted chemotherapy) and Pucotenlimab (an immunotherapy)—before and after surgery can improve outcomes for people with recurrent head and neck cancer that can still be removed. About 102 pa…

This study compares two balloon treatments used after placing a stent in long blockages of the leg arteries. About 180 people with peripheral artery disease will receive either a drug-coated balloon or a standard balloon. The goal is to see which keeps the artery open longer and …

This study tests whether using a smart electric toothbrush with an app and flossing can control gum inflammation as well as getting a professional dental cleaning. 92 adults with mild gum disease will be split into two groups: one uses the smart toothbrush alone, the other gets a…

This phase 3 trial tests a new treatment for people with high-risk head and neck cancer who cannot receive the standard chemotherapy drug cisplatin. Participants receive radiation therapy combined with two drugs (nimotuzumab and benmelstobart) to see if this approach improves dis…

This study tests three common cleaning aids—superfloss, interdental brushes, and a water flosser—in 18 adults with full-arch implant-supported dentures. Each person uses one method for three months, then switches to the next, so everyone tries all three. The goal is to find which…

This study is testing whether simpler methods like mouth photos, dental X-rays, saliva tests, and questionnaires can accurately detect gum disease (gingivitis and periodontitis) compared to a standard full-mouth exam. About 2,000 adults from five centers will participate. The goa…

This study aims to develop and validate an artificial intelligence system that uses color analysis of dental scans to objectively diagnose gum redness around dental implants. The goal is to reduce variability among clinicians and improve early detection of inflammation. The study…

This study tests whether taking taurine granules before daily radiation can reduce painful mouth sores and skin burns in 160 head and neck cancer patients. Half get taurine, half get a placebo, and researchers track side effect severity. If effective, it could offer a simple, low…

This study looks at why some people aged 60 and older have trouble understanding speech in noisy settings, even though their standard hearing tests are normal. Researchers will use hearing tests and brain scans to see if the problem is related to how the brain processes sound tim…

This study will follow 5,000 children and teens with hearing loss and normal hearing over time. Researchers will measure changes in hearing, speech, language, and brain scans to see how different treatments—like hearing aids, cochlear implants, or gene therapy—affect development.…

This study aims to find biological markers in saliva, gum fluid, and tissue that can predict which people with mild gum inflammation will develop serious periodontitis. Researchers will use advanced techniques to analyze samples from 228 adults aged 18-40 with gingivitis or early…