Shanghai Mental Health Center

This study tests a new type of brain stimulation that sends paired pulses to the cerebellum and prefrontal cortex. The goal is to reduce cravings and improve cognitive flexibility in 90 adults with moderate to severe methamphetamine use disorder. Participants will receive either …

This study tests whether high-intensity brain stimulation (HI-tACS) can help people with gambling disorder. Researchers will give 60 adults either real or fake stimulation to see if it reduces gambling urges and improves thinking. Participants are followed for three months to che…

This study tests a smartphone app that uses motion-sensing cognitive games and interactive stories to help people with schizophrenia improve their thinking, mood, and daily skills. 84 hospitalized adults will be randomly assigned to use the app or receive standard care. The goal …

This study tests whether group gaming activities can reduce harmful gaming habits in people with gaming disorder. About 100 participants will be split into two groups: one receives the gaming-based program, the other serves as a control. The goal is to see if the program lowers s…

This trial tests whether a 12-week online program that blends family-based treatment with dialectical behavior therapy can reduce the heavy burden often felt by caregivers of teenagers with anorexia nervosa. Caregivers are randomly assigned to either this combined program or a ge…

This study tests whether personalized music playlists can reduce stress, anxiety, and depression in adults. 2,000 participants will either receive music designed to match and gradually shift their mood, or no music. The goal is to see if this simple, non-invasive approach can imp…

This small early study tests whether a gentle brain stimulation technique called temporal interference (TI) can safely reduce PTSD symptoms in 5 adults. Participants will receive TI stimulation and have their brain activity measured with MRI, MEG, and EEG. The goal is to see if s…

This study tests whether playing specially designed somatosensory video games for 2 months can improve thinking skills in people with schizophrenia. The games train five cognitive functions like memory and attention using body movements. Researchers will enroll 84 stable patients…

This study tests a new type of transcranial magnetic stimulation (TMS) that targets three brain areas at once to help with negative symptoms of schizophrenia, like lack of motivation, emotion, or social interest. Researchers will enroll 64 people with first-episode schizophrenia …

This study tests a new 10-week group therapy called Mindfulness-Based Exposure Therapy (MBET) for people with obsessive-compulsive disorder (OCD). The therapy combines mindfulness training with exposure exercises to help patients better manage distress and complete treatment. Res…

This study tests a device that uses gentle electrical fields to stimulate brain areas linked to OCD. 18 adults with moderate-to-severe OCD will receive either real or sham stimulation for 7 days. Researchers will measure symptom changes and use brain scans to understand how it wo…

This study looks at how well and how safely a new sleep medication, lemborexant, works for people who have both a mental health condition and trouble sleeping. About 121 adults will take the drug for 8 weeks, and researchers will track changes in their sleep quality and any side …

This study investigates how the gut-brain axis—the communication network between gut bacteria and the brain—might be involved in pediatric obsessive-compulsive disorder (OCD). Researchers will compare gut microbiome, blood metabolites, brain imaging, and EEG data from children wi…

This study will follow 1,200 people with schizophrenia in Shanghai for up to 5 years. Researchers will track symptoms, aggression, and other mental health changes to understand how the disease progresses. The goal is to build a long-term database and biobank to improve future car…

This observational study is testing whether a computer can predict when someone with bipolar disorder might relapse. Researchers will collect voice, text, eye movements, and brain signals from 200 patients and 200 healthy volunteers. The goal is to build a model that spots early …

This study looks at how a new, non-invasive brain stimulation technique called temporal interference (TI) affects social reward processing in people with depression. Researchers will use brain scans and tests to see if TI can change brain activity linked to social function. The g…