Shandong Cancer Hospital And Institute

This study tests a new treatment plan for people with advanced liver cancer that has either spread to a few other spots or formed a blood clot in the main liver vein. The treatment combines chemotherapy directly into the liver artery, two immunotherapy drugs, and targeted radiati…

This study tests whether a newer oral chemotherapy drug (TAS-102) works better than the current standard (capecitabine) when given with radiation before surgery for locally advanced rectal cancer. About 210 adults aged 18-75 with stage II or III rectal cancer will take part. The …

This study tests a new drug called ivonescimab, which targets the immune system and tumor blood vessels, combined with targeted radiation and chemotherapy for people with locally advanced pancreatic cancer that cannot be removed by surgery. The goal is to see if this combination …

This study tests a new combination of the drug cadonilimab plus chemotherapy and radiation for people whose endometrial cancer has come back or spread to a few other spots. About 30 participants will receive the treatment and be monitored for tumor shrinkage, survival, and side e…

This study tests whether adding the targeted drug nimotuzumab to standard radiation therapy helps control advanced head and neck cancer better than radiation alone. It is for 335 adults whose cancer has spread locally but cannot have platinum chemotherapy. The main goal is to see…

This study tests whether adding the immunotherapy drug sintilimab to standard chemotherapy and radiation can help people with pancreatic cancer that cannot be removed by surgery. The trial will enroll 25 adults who have not had prior treatment for their cancer. Researchers will m…

This study looks at colorectal cancer patients whose disease is under control (no evidence of cancer) but later develop a few new lung spots. Instead of starting chemotherapy right away, doctors will treat those spots with surgery or radiation and then watch closely. The goal is …

This study tests a combination of two drugs (fruquintinib and sintilimab) with or without radiation therapy for people with colorectal cancer that has spread to the liver and hasn't responded to two prior treatments. The goal is to see if this approach can control the cancer long…

This study tests whether adding a precise form of radiation (SBRT) to standard drug therapy helps people with advanced liver cancer (BCLC stage C) live longer. About 184 adults aged 18-70 with good liver function will be randomly assigned to receive either drug therapy alone or d…

This study compares a new type of radiation therapy (SFRT) to standard radiation for people with large soft tissue sarcomas (tumors at least 5 cm). About 106 adults aged 18-70 will be randomly assigned to one of the two treatments. The goal is to see if SFRT can shrink tumors bet…

This study tests whether adding the antifungal drug posaconazole to standard immunotherapy and chemotherapy can help more women with triple-negative breast cancer achieve a complete response before surgery. About 72 women with early-stage, high-risk breast cancer will participate…

This study tests a new, easier-to-absorb version of megestrol acetate (a drug that stimulates appetite) in 56 people with advanced pancreatic cancer who are losing weight and appetite. The goal is to see if it helps them gain weight, feel better, and improve their quality of life…

This study looks at three doses of olanzapine (2.5 mg, 5 mg, and 10 mg) to find the best balance between preventing nausea and vomiting from strong chemotherapy and reducing side effects like sleepiness. It will analyze data from about 2,000 adult patients with solid tumors. The …

This study looks at 300 people with HER2-positive breast cancer that hasn't spread. Researchers want to see if those with very high HER2 levels respond differently to a combination of two targeted drugs (trastuzumab and pertuzumab). The goal is to understand if HER2 levels can pr…