Rush University Medical Center

This trial tests whether a church-based program combining physical activity education and a walking group can improve physical function in adults aged 40 and older who have mobility limitations. Participants attend weekly 90-minute sessions for 24 weeks. The study measures change…

This study tests whether giving menstrual cups to economically vulnerable women in Kenya can lower rates of bacterial vaginosis (BV) and sexually transmitted infections (STIs). The cup is a reusable silicone device that collects menstrual blood and can be worn during sex. Researc…

This study compares two methods to prevent infections during first-time penile implant surgery for erectile dysfunction. One group receives the standard antibiotic rinse, the other uses Irrisept, a simpler cleaning solution. Researchers will follow 200 men for one year after surg…

This study tests a team-based approach to help African American and Latinx adults with uncontrolled type 2 diabetes lower their blood sugar levels. Participants will receive extra support from a multidisciplinary team, while a comparison group gets usual care plus educational mat…

This study tests whether adding a patient's own bone marrow stem cells during ACL reconstruction helps the graft heal better. One hundred adults with recent ACL tears will receive either stem cells or a sham procedure. The main goal is to see if the graft looks healthier on MRI a…

This study tests a 6-month church-based program to help African Americans with uncontrolled high blood pressure. The program includes Bible study sessions led by the pastor and small group meetings focused on diet and exercise. A community health worker provides extra support if …

This study looks at whether taking a common ulcerative colitis medication (5-ASA) at a specific time of day—morning or evening—can better reduce hidden inflammation. Thirty-two adults with inactive UC will try both timing schedules over three months. Researchers will measure infl…

This study tests whether injecting a concentrated sample of a patient's own bone marrow into the knee right after meniscus surgery can slow down or prevent arthritis. One hundred adults with a torn meniscus will receive either the bone marrow injection or a saltwater placebo, and…

This early-phase study planned to test whether injecting the seasonal flu vaccine directly into breast tumors could help the immune system attack the cancer. It was designed for women with triple-negative or HER2+ breast cancer who were already scheduled for chemotherapy before s…

This study tests whether using advanced MRI scans to guide radiation therapy can reduce side effects for men with localized prostate cancer. Depending on their MRI results, patients receive either a short course of radiation or a longer treatment with a targeted boost to visible …

This study tests whether injecting a patient's own blood into the chest tube can stop prolonged air leaks after lung cancer surgery. About 60 adults who still have an air leak three days after surgery will receive the blood patch. Researchers will check if it reduces hospital sta…

This study tests whether a 6-month program combining Bollywood-style dance classes and a fitness tracker can increase physical activity and improve metabolic health in South Asian Indian immigrant women aged 40-65 who are not very active. The goal is to see if this culturally tai…

This study tests a digital program called BrotherlyACT designed for young Black males aged 15-24 who have experienced trauma. The program includes life skills coaching, safety planning, and an AI chatbot to help reduce violence and substance use. 300 participants will be split in…

This study tests whether following the MIND diet for 2 to 3 years can slow cognitive decline and reduce dementia risk in people aged 55 and older who have had an ischemic stroke. The MIND diet combines elements of the Mediterranean and DASH diets, with extra emphasis on leafy gre…

This study tests a program where Black mothers and their 9th- or 10th-grade daughters work together to increase physical activity and improve diet, aiming to prevent obesity. About 120 pairs will join, with daughters at higher risk due to weight. The program uses activity tracker…

This study tests a virtual behavioral therapy (Functional Behavioral Training) for children aged 2-12 with genetic syndromes like Fragile X, Angelman, or Rett syndrome who have challenging behaviors. The therapy teaches parents how to identify what triggers problem behaviors and …

This study tests whether training early intervention providers in Reciprocal Imitation Training can help children with autism improve imitation and communication skills. The program involves 440 children and their caregivers, with providers learning simple strategies during play.…

This study tests a 12-week program called PERSEVERE for 502 family caregivers of people with Lewy body dementia (LBD). Caregivers are matched with a trained peer mentor who guides them through lessons on LBD and provides support. The goal is to see if this reduces caregiver strai…

This pilot study tests whether a 4-month program that encourages people from underserved communities to engage in rewarding community activities can improve depression symptoms, physical activity, and weight. The study involves 102 adults with elevated depressive symptoms and at …

This study compares a one-week virtual talk therapy (Cognitive Processing Therapy) to a five-day relaxation training for reducing PTSD symptoms. About 140 adults with PTSD will participate to see which approach works better and how. The goal is to find faster, more effective ways…

This study follows very low birth weight infants whose mothers received an economic intervention to encourage providing their own milk. Researchers will assess the children's thinking, language, motor skills, body composition, and healthcare costs at age 2. The goal is to underst…

This study follows children who were born very preterm and took part in a trial that provided financial support to help mothers provide their own milk during NICU care. Researchers will assess the children's thinking skills, behavior, growth, and overall costs to society at presc…

This study compares three psychological treatments—CBT, ACT, and EAET—for adults with chronic back or neck pain. Researchers want to understand how each therapy works and which patients benefit most. 408 participants will receive weekly online therapy for 8 weeks and be followed …

This study looks at how Western habits—like drinking alcohol and eating late—might raise the risk of colorectal cancer. Twelve adults who have had colon polyps in the past will try four different weekly routines, including eating at normal times or late, with or without alcohol. …

This study looks at ways to get patients to complete follow-up surveys after shoulder surgery. About 400 adults having shoulder arthroscopy will either receive education about the importance of surveys or get Amazon gift cards for completing them. The goal is to see which method …

This study aims to find out if extra digestive juices from the new pancreas cause weight gain after a pancreas transplant. Researchers will measure a digestive enzyme in the stool of 50 transplant recipients and see if it relates to how much weight they gain. The goal is to bette…

This study compares two types of hip replacement implants to see if one raises metal levels in the blood more than the other. Fifty-two adults getting a hip replacement will be randomly assigned to receive either a standard implant or a newer 'dual mobility' design. Researchers w…

This study looks at whether people can drive safely right after minor surgery with newer, short-acting anesthesia drugs. About 625 adults who have minor procedures (like hand or foot surgery) will take a driving simulator test before leaving the clinic. The goal is to see if cert…

This study follows 22 adults undergoing spinal fusion surgery (LLIF or ALIF) to see how long hip and leg weakness lasts. Researchers measure muscle strength before surgery and again at 6 weeks, 12 weeks, and 6 months after. The goal is to give patients a clearer idea of when they…