Pakistan Institute Of Medical Sciences

This study compares two approved antipsychotic drugs, risperidone and cariprazine, in 50 adults with bipolar 1 disorder experiencing acute mania. Participants take one of the drugs for 6 weeks, and doctors measure how well symptoms improve using a standard mania rating scale. The…

This study tests whether a low daily dose of the acne drug isotretinoin can clear moderate to severe acne as effectively as the standard dose, but with fewer side effects. About 164 people aged 18-45 will be randomly assigned to one of two dose groups. Researchers will track acne…

This study will test whether a newer cream called tapinarof works better than the standard betamethasone cream for mild-to-moderate plaque psoriasis. About 120 adults will use one of the two creams daily for up to 12 weeks. The main goal is to see how many people get at least a 7…

This study tests whether adding small ridges (like natural ones) to the roof of dentures helps people with no teeth feel more satisfied and improves their quality of life. Sixty adults aged 45 to 80 who need new dentures will try both a standard denture and one with ridges, then …

This study compares two types of wound dressings—chlorhexidine-impregnated gauze and povidone-iodine dressing—to see which one better prevents infection and speeds up healing in people with fresh, clean-contaminated wounds from an injury. About 176 adults aged 18 to 65 will take …

This study tests whether a home-based cardiac rehabilitation program can improve quality of life and health behaviors in heart patients living in low-resource settings in Pakistan. The program includes diet advice, exercise suggestions, medication reminders, and counseling, deliv…

This lab study compares two ways to prepare a root canal before cleaning it: using hand files or a mechanical rotary tool. Researchers will test 60 extracted single-rooted teeth to see which method keeps the working length more accurate. The goal is to improve root canal success,…

This study compares two techniques for closing the wound after a chest tube is removed: the purse-string suture and the plug method. Researchers want to see which one leads to better healing, fewer complications like air leaks or infections, and higher patient satisfaction. About…

This lab study will test 60 extracted human teeth to see if a special coating on gutta-percha (the material used to fill root canals) helps create a tighter seal compared to standard gutta-percha. Both groups will use the same bioceramic sealer. The goal is to find which combinat…