New Approaches To Neuroblastoma Therapy Consortium

This early-phase study tested an intravenous form of the drug fenretinide in 17 children whose neuroblastoma had returned or resisted treatment. The main goals were to find the safest dose and understand side effects. Researchers also looked at how the drug moved through the body…

This study tested a new daily pill called lorlatinib in 65 children and young adults with a type of nerve cancer (neuroblastoma) that had come back or not responded to treatment. The drug targets a specific genetic change in the cancer cells. The main goals were to find the safes…

This early-phase study tested a treatment for children with high-risk neuroblastoma that had come back or not responded to standard therapy. The approach combined a radioactive drug (131I-MIBG) that targets tumor cells with two chemotherapy drugs (irinotecan and vincristine). The…

This study tested a treatment for children with high-risk neuroblastoma that had come back or not responded to standard therapy. It combined a radioactive drug (MIBG) with strong chemotherapy, followed by a stem cell transplant to restore blood cells. The goal was to see if this …

This early-stage trial tested a combination of two chemotherapy drugs (irinotecan and temozolomide) plus an antibiotic (cefixime) in 30 children whose high-risk neuroblastoma had come back or not responded to treatment. The main goal was to find the safest dose of oral irinotecan…

This early-phase trial tested a two-part radioactive treatment (I-MIBG) followed by a stem cell transplant in 18 children with neuroblastoma that didn't respond to standard therapy. The goal was to find the safest highest dose of radiation that could be given in two quick infusio…

This early-phase trial tested an oral powder form of the drug fenretinide in 80 children whose neuroblastoma had come back or not responded to standard treatment. The main goals were to find the safest dose and understand side effects. The study also looked at how the drug moves …