New hope for neuroblastoma: targeted pill shows promise in early trial
NCT ID NCT03107988
First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 24 times
Summary
This early-phase study tested a daily pill called lorlatinib in 65 people with ALK-driven neuroblastoma, a rare nerve cancer that had come back or not responded to standard treatments. The goal was to find the safest dose and check for side effects, both when given alone and with chemotherapy. While not a cure, this targeted approach aims to better control the disease in patients who have few other options.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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C.S Mott Children's Hospital
Ann Arbor, Michigan, 48109, United States
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Children Hospital of Colorado
Aurora, Colorado, 80045, United States
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Children's Healthcare of Atlanta
Atlanta, Georgia, 30322, United States
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Children's Hospital Los Angeles
Los Angeles, California, 90027-0700, United States
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Children's Hospital and Regional Medical Center - Seattle
Seattle, Washington, 98105, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104-4318, United States
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Childrens Hospital Boston, Dana-Farber Cancer Institute.
Boston, Massachusetts, 02115, United States
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Cook Children's Healthcare System
Fort Worth, Texas, 76104, United States
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Hospital for Sick Children
Toronto, Ontario, M5G 1X8, Canada
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Institut Curie
Paris, Cedex, 05, France
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Royal Marsden Hospital
Sutton, Surrey, SM25NG, United Kingdom
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UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco, California, 94143, United States
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University of Chicago, Comer Children's Hospital
Chicago, Illinois, 60637, United States
Conditions
Explore the condition pages connected to this study.