Radioactive cocktail shows promise against tough childhood cancer
NCT ID NCT00253435
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tested a combination of a radioactive drug (MIBG), intensive chemotherapy, and a stem cell transplant in 50 children with relapsed or hard-to-treat neuroblastoma. The goal was to see if this approach could shrink tumors and improve survival. The treatment aims to deliver radiation directly to cancer cells while using high-dose chemo to kill remaining cells, followed by a stem cell rescue to restore blood cell production.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Iodine I 131 metaiodobenzylguanidine (MIBG) plus carboplatin, etoposide, melphalan, and radiation
What this could lead to
If it works, this could offer a more effective treatment option for children with hard-to-treat neuroblastoma, potentially improving response rates and survival.
What could go wrong
This is a small, early-phase trial (50 patients) with no control group, so results may not apply broadly. The treatment involves high-dose chemotherapy and radiation, which can cause severe side effects like infection and organ damage.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus
Atlanta, Georgia, 30322, United States
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C.S. Mott Children's Hospital at University of Michigan Medical Center
Ann Arbor, Michigan, 48109-0286, United States
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Children's Hospital and Regional Medical Center - Seattle
Seattle, Washington, 98105, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104-4318, United States
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Childrens Hospital Los Angeles
Los Angeles, California, 90027-0700, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229-3039, United States
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Cook Children's Medical Center - Fort Worth
Fort Worth, Texas, 76104, United States
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Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute
Boston, Massachusetts, 02115, United States
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Hospital for Sick Children
Toronto, Ontario, M5G 1X8, Canada
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Lucile Packard Children's Hospital at Stanford University Medical Center
Palo Alto, California, 94304, United States
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Morgan Stanley Children's Hospital of New York-Presbyterian
New York, New York, 10032, United States
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Texas Children's Cancer Center and Hematology Service at Texas Children's Hospital
Houston, Texas, 77030-2399, United States
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UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco, California, 94143, United States
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University of Chicago Comer Children's Hospital
Chicago, Illinois, 60637, United States
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University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
Madison, Wisconsin, 53792-6164, United States