New hope for kids with resistant neuroblastoma: targeted radiation plus chemo tested

NCT ID NCT00509353

Completed Disease control Sponsor: New Approaches to Neuroblastoma Therapy Consortium Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tested a combination of two chemotherapy drugs (irinotecan and vincristine) plus a radioactive drug (131I-MIBG) in 26 children with high-risk neuroblastoma that had come back or not responded to standard treatment. The goal was to find the safest dose of the radioactive drug when given with the chemo. The approach aims to deliver radiation directly to tumor cells while using chemo to stop cancer growth.

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Conditions

The condition(s) this trial relates to.

neuroblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEUROBLASTOMA

Contacts and locations

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Locations

AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus

Atlanta, Georgia, 30322, United States
C.S. Mott Children's Hospital at University of Michigan Medical Center

Ann Arbor, Michigan, 48109-0286, United States
Children's Hospital Boston

Boston, Massachusetts, 02115, United States
Children's Hospital and Regional Medical Center - Seattle

Seattle, Washington, 98105, United States
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104-4318, United States
Childrens Hospital Los Angeles

Los Angeles, California, 90027-0700, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229-3039, United States
Cook Children's Medical Center - Fort Worth

Fort Worth, Texas, 76104, United States
Lucile Packard Children's Hospital at Stanford University Medical Center

Palo Alto, California, 94304, United States
UCSF Helen Diller Family Comprehensive Cancer Center

San Francisco, California, 94115, United States
University of Chicago Comer Children's Hospital

Chicago, Illinois, 60637, United States
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center

Madison, Wisconsin, 53792-6164, United States

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