Can a Two-Drug combo outsmart returning childhood cancers?
NCT ID NCT00918320
First seen Aug 19, 2026 · Last updated Aug 19, 2026
Summary
This phase 2 trial is testing whether combining two chemotherapy drugs—temozolomide and topotecan—can help children with neuroblastoma, brain tumors, or other solid tumors that have come back or not responded to standard treatment. Participants receive temozolomide by mouth and topotecan by IV once daily for five days per cycle. The main goal is to see how often tumors shrink or disappear, while also tracking side effects and how long any benefit lasts.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- A combination of two chemotherapy drugs: temozolomide (taken by mouth) and topotecan (given by IV infusion).
- What this could lead to
- If effective, this drug combination could offer a new treatment option for children with hard-to-treat or returning solid tumors, potentially slowing disease or shrinking tumors.
- What could go wrong
- This is an early-phase trial, so the combination may not work for all tumor types. Chemotherapy also carries risks like low blood counts, fatigue, and increased infection risk.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for BRAIN TUMORS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Institut Gustave Roussy
Villejuif, 94805, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a grid of radiation beams shrink tumors that resist standard treatment?
- A 17-point quiz may reveal which older cancer patients need extra care
- Can a new pill shrink Hard-to-Treat tumors?
- Can a new drug shrink Hard-to-Treat gynecological tumors?
- Blood test may spare cancer patients unneeded iron infusions
- Can a new injection shrink Hard-to-Treat tumors?