New hope for kids with tough neuroblastoma: fenretinide powder trial begins

NCT ID NCT00295919

Completed Disease control Sponsor: New Approaches to Neuroblastoma Therapy Consortium Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial tested a new oral form of the chemotherapy drug fenretinide in 80 children whose neuroblastoma had come back or resisted standard treatment. The goal was to find the safest dose and understand side effects. Researchers also looked at how the body processes the drug and whether adding another drug (ketoconazole) could improve its effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: fenretinide LXS oral powder (a chemotherapy drug)
What this could lead to: If it works, this could point toward a new treatment option for children with hard-to-treat neuroblastoma.
What could go wrong: This is an early Phase 1 trial focused on safety and dosing, not yet on effectiveness. It may not lead to a successful treatment, and side effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neuroblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEUROBLASTOMA

Contacts and locations

Locations

AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish Rite Campus

Atlanta, Georgia, 30342, United States
C.S. Mott Children's Hospital at University of Michigan Medical Center

Ann Arbor, Michigan, 48109-0286, United States
Children's Hospital Boston

Boston, Massachusetts, 02115, United States
Children's Hospital and Regional Medical Center - Seattle

Seattle, Washington, 98105, United States
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104-4318, United States
Childrens Hospital Los Angeles

Los Angeles, California, 90027-0700, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229-3039, United States
Cook Children's Medical Center - Fort Worth

Fort Worth, Texas, 76104, United States
Lucile Packard Children's Hospital at Stanford University Medical Center

Palo Alto, California, 94304, United States
UCSF Helen Diller Family Comprehensive Cancer Center

San Francisco, California, 94143, United States
University of Chicago Comer Children's Hospital

Chicago, Illinois, 60637, United States

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