National Institute On Drug Abuse (nida)

This study tests whether a combination of two medications (extended-release naltrexone and bupropion) can help people with moderate to severe methamphetamine use disorder reduce their drug use. The study will enroll 360 adults who want to stop or cut down on meth. Participants wi…

This study tests spironolactone, a drug used for high blood pressure, in 20 adults with alcohol use disorder. Participants stay at a clinic for four 7-day periods, taking the drug or a placebo, and then drink alcohol under supervision. The goal is to see how the body handles the …

This study tests whether semaglutide, a medication used for diabetes and weight loss, can safely reduce alcohol drinking in people with alcohol use disorder. About 67 adults will receive either semaglutide or a placebo shot weekly for 20 weeks, along with behavioral therapy and b…

This study aims to build a large data repository by collecting information from 10,000 adults who have used alcohol or drugs in the past 30 days. Participants will use a smartphone app that tracks things like screen time, app usage, and movement, and complete daily and monthly su…

This study explores how a non-invasive brain stimulation technique called TMS changes brain activity related to learning and decision-making. Researchers will recruit 600 healthy adults aged 18-45 to perform computer tasks while receiving TMS or undergoing brain scans. The goal i…

This study looks at how nicotine changes brain activity in people with major depressive disorder (MDD) compared to those without. Researchers will use MRI scans to measure brain function after giving participants either nicotine or a placebo. The goal is to understand why people …

This study aims to develop better MRI techniques to see how drug addiction changes the brain. Researchers will scan the brains of up to 1,000 adults, including smokers, non-smokers, and people who use drugs or not. The goal is to improve our understanding of addiction and pave th…

This study looks at how people with opioid-use disorder learn and make decisions compared to those without addiction. Participants will complete a computer task where shapes are paired with different food odors. The goal is to understand the brain processes that make it hard to c…

This study screens up to 10,000 people aged 18 and older, with or without substance or alcohol use disorders, to find volunteers for future research at NIDA. Participants undergo a single visit with tests like physical exams, blood work, memory tests, and mental health evaluation…

This study aims to create and test computer tasks that measure how people learn and make decisions. Researchers want to better understand substance use disorders by studying healthy adults aged 18-45 from the Baltimore area. Participants will complete tasks involving smells, tast…

This study looks at how suvorexant, a medicine used for insomnia, changes brain function in people who smoke or vape daily and in non-smokers. Researchers want to see if it can reduce cravings and help understand addiction. About 140 smokers and 80 non-smokers will take part, wit…

This study looks at how transcranial magnetic stimulation (TMS) changes brain activity in healthy adults. Researchers want to understand these effects to design better treatments for drug addiction. Participants will have brain scans before, during, and after TMS. The study invol…

This study looks at how different environments and activities—like virtual reality, games, or watching videos—affect drinking urges and mental health in people with alcohol use disorder. About 44 adults will take part in up to 10 visits, using an app to track their mood and drink…