King's College London

This study tests whether taking capsules of processed donor stool (fecal transplant) can lower the risk of serious infections and hospital visits in people with liver cirrhosis. About 300 adults with alcohol-related or fatty liver cirrhosis will receive either the transplant or a…

This study tests a smartphone app called Orbi, designed to help people with long-term physical illnesses manage feelings of distress, anxiety, or depression. Researchers will compare the app plus usual charity support against charity support alone in 60 adults. The goal is to see…

This study is testing whether a daily probiotic drink can help reduce skin inflammation and improve immune function in women going through perimenopause. Thirty women aged 40-50 with acne will drink either a probiotic or a placebo for eight weeks. Researchers will measure immune …

This study focuses on improving how doctors spot early signs of chronic venous insufficiency (CVI) in people with dark skin tones, who are often underdiagnosed. Researchers will interview patients about their experiences and test new assessment techniques, including special photo…

This study compares brain energy use and glutamate levels between 75 people with schizophrenia and healthy volunteers. Participants undergo MRI and PET scans to measure glucose use, lactate, and brain activity. The goal is to understand biological differences, not to test a treat…

This study tests whether a brief online video about cannabis withdrawal can increase awareness and insight in daily cannabis users. About 100 adults who use cannabis at least 25 days a month will watch either an educational video or a relaxation video. The goal is to see if the e…

This study looks at whether minocycline, an antibiotic that also fights inflammation, can help people who have both obesity and depression that hasn't improved with other treatments. Researchers will check if it's practical and acceptable for 35 participants to take minocycline f…

This study looks at whether diroximel fumarate, a drug already used for multiple sclerosis, can increase a natural antioxidant called glutathione in the brains of people with schizophrenia. Thirty adults with stable schizophrenia will take the drug for two weeks, then either cont…

This study will follow 5,000 people who receive newer devices to treat brain aneurysms. Researchers want to see how safe and effective these devices are, and what factors might cause an aneurysm to come back. The goal is to improve future treatment decisions.

This study looks at whether regularly massaging a baby's skin can change how their immune system works. Researchers will compare daily massage, twice-weekly massage, and no massage over 8 weeks in 109 healthy babies up to 6 months old. They will measure immune signals and skin he…

This study takes tumor samples from breast cancer that has spread to the brain or other parts of the body and grows them in the lab as mini-tumors (organoids). Researchers will test these mini-tumors with different treatments to see if their response matches what happens in the p…