Institut National De La Santé Et De La Recherche Médicale, France

This study tested a higher dose of a new nasal vaccine (BPZE1) for whooping cough in 54 healthy adults aged 18 to 32. The goal was to see if the vaccine is safe and can colonize the nose to trigger immunity. Researchers monitored side effects and checked for the vaccine strain in…

This study tested whether a flu vaccine (H1N1) is safe and works well in people who have had a kidney transplant. 122 adults who had a transplant at least 6 months ago and were on immune-suppressing drugs took part. The main goal was to see if the vaccine triggered a strong immun…

This early-phase study tested the safety of giving sitagliptin, a diabetes drug, to 14 liver cancer patients for three weeks before they had surgery to remove part of their liver. The goal was to see if the drug could help the immune system better attack the tumor. The study focu…

This study tested a drug called anakinra in 24 children and young adults with severe systemic juvenile idiopathic arthritis (SO-JIA) that did not respond well to steroids. For the first month, half received anakinra and half received a placebo, then everyone received anakinra for…

This study tested a new way to take heart MRI pictures while patients breathe normally, instead of holding their breath. Thirty adults with heart disease (ischemic or dilated cardiomyopathy) had both standard breath-hold and new free-breathing scans. The goal was to see if the ne…

This study looked at whether a protein called EG-VEGF in the blood of pregnant women could help predict serious conditions like pre-eclampsia (high blood pressure) and poor fetal growth. Researchers measured EG-VEGF levels in 142 women around 14-18 weeks of pregnancy. The goal wa…

This study tested whether a brain scan (fMRI) can detect early Parkinson's disease by looking at a small area called the superior colliculus, which processes visual information. Researchers compared 23 newly diagnosed Parkinson's patients with healthy volunteers to see if brain a…

This study tested whether promoting a free web and mobile tool called StopBlues in local communities could lower suicide rates and psychological distress. Over 100,000 adults from 42 French areas took part. Some communities promoted the tool, while others did not, and researchers…

This study tested a personalized program combining physical activity, cognitive training, and nutritional advice to prevent mobility disability in 210 older adults (60+) who were frail or pre-frail. Participants were followed to see if they could still walk 400 meters. The goal w…

This study tested whether healthy volunteers could collect their own blood drops using a simple finger-prick method during brief periods of weightlessness on parabolic flights. The goal was to see if this technique works in microgravity for measuring caffeine levels after drinkin…

This study looked at whether a non-invasive brain stimulation technique called paired associative stimulation (PAS) can help people who had a stroke regain hand movement. Researchers tested two types of PAS that use visual or cerebellar signals, along with a sham (fake) treatment…

This study looked at how children and adults with autism pay attention to emotions and changes compared to people without autism. Researchers used brain scans (EEG, MRI) to measure brain activity. The goal was to better understand these differences, not to test a treatment. 120 p…

This study looked at whether measuring natural chemicals in urine over 24 hours could help monitor cancer therapy. Researchers collected multiple urine samples from 32 people with advanced colorectal cancer and healthy volunteers. The goal was to see if daily rhythms of these che…

This study used brain scans (fMRI) to understand how shared cultural memories—like those from a visit to a World War II memorial—affect the way individuals remember personal experiences. Twenty-seven healthy adults participated. The goal was to see which brain areas handle collec…

This study looked at how healthy young adults (ages 18-35) can intentionally suppress unpleasant memories. Using brain wave recordings (EEG) and measures like heart rate and skin response, researchers aimed to understand the timing and nature of the brain processes involved. The …

This study looked at 16 people with severe facial paralysis to see how their brains process facial movements and emotions before and after reconstructive surgery. Using a non-invasive brain scan called magnetoencephalography (MEG), researchers measured brain activity during motor…

This study looked at how two brain regions—the cerebellum and striatum—talk to each other in people with genetic forms of dystonia (ADCY5 and PRRT2 mutations). Researchers used MRI scans and mild brain stimulation to compare patients with healthy volunteers. The goal was to bette…

This study looked at how spinal nerves work in people recently diagnosed with ALS compared to healthy volunteers. The goal was to find early signs of nerve damage that could help doctors diagnose ALS sooner and track how treatments work. About 100 people took part, and the resear…

This study tested whether adding a quick TB test (Xpert Ultra) to standard care helps find tuberculosis earlier in young children hospitalized with severe pneumonia. Over 2,500 children in six high-TB countries took part. The goal was to see if early detection and treatment reduc…

This study looked at the DNA of 2500 people, including those with Parkinson's disease and healthy volunteers, to find genetic mutations linked to the condition. Researchers focused on several genes, including parkin, to better understand how these changes contribute to the diseas…

This study measured COVID-19 antibodies in over 2,800 primary care health workers (doctors, pharmacists, dentists) and their household members in France. The goal was to understand how many had been exposed to the virus and how their immune systems responded. Results help guide p…

This study looked at over 1,000 mothers and daughters to understand how bone strength and fracture risk are passed down through families. Researchers compared bone scans and density between daughters whose mothers had fragile bones and those whose mothers did not. The goal was to…

This study looked at how the cerebellum, a brain area key for movement, influences learning and plasticity in people with dystonia and healthy volunteers. Researchers used mild brain stimulation to temporarily change cerebellar activity and measured effects on brain responses. Th…

This study looked at how two brain areas—the cerebellum and the supplementary motor area—help us keep our balance when we start walking. Twenty healthy adults had their balance and walking measured before and after temporarily disrupting these brain regions with a non-invasive ma…