New hope for kids with severe arthritis: drug may tame symptoms and cut steroid use

NCT ID NCT00339157

Completed Disease control Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Source: ClinicalTrials.gov ↗

First seen Feb 20, 2026 · Last updated Jun 11, 2026 · Updated 18 times

Summary

This study tested a drug called anakinra in 24 children and young adults (ages 2-20) with severe systemic-onset juvenile idiopathic arthritis (SO-JIA) that did not respond well to steroids. For the first month, half received anakinra and half received a placebo, then all received anakinra for 11 more months while slowly reducing steroids. The goal was to see if anakinra could improve arthritis symptoms and help patients use less steroids.

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Contacts and locations

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Locations

Bordeaux CHU

Bordeaux, 33000, France
Hopital Lyon Edouard Herriot

Lyon, 69437, France
Kremlin-Bicetre Hospital

Paris, 94270, France
Nancy Hopital d'Enfants

Nancy, 54511, France
Pediatric Immuno-Hematology and Rheumatology Unit, Necker-Enfants Malades Hospital, 149 rue de Sevres

Paris, 75015, France
Robert Debre Hospital

Paris, 75019, France

Conditions

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SYSTEMIC-ONSET JUVENILE IDIOPATHIC ARTHRITIS SYSTEMIC-ONSET JUVENILE IDIOPATHIC ARTHRITIS