Georgetown University

This study tests a drug called sacituzumab govitecan in adults with advanced thymoma or thymic carcinoma that has worsened after at least one prior treatment. Participants receive the drug intravenously once weekly for two weeks, then a week off, and continue until the cancer pro…

This study is for people with early-stage HPV-positive throat cancer. Standard treatment uses full-dose radiation plus chemotherapy, which can cause long-term side effects. The study tests whether giving only lower-dose radiation (no chemo) can keep the cancer from coming back wh…

This study tests a combination of two drugs, pembrolizumab and lenvatinib, in people with advanced cervical cancer that has not responded to previous treatment. The goal is to see if this combination can shrink tumors or slow cancer growth. About 35 participants will receive the …

This study tests a combination of three drugs—daratumumab, nivolumab, and a KRAS vaccine—in people with advanced pancreatic cancer or non-small cell lung cancer that has not responded to prior treatment. The goal is to see if this approach can shrink tumors or slow cancer growth.…

This study looks at whether people with HPV-positive throat cancer who had surgery can safely receive a lower radiation dose to a smaller area (just the neck, not the original tumor site). The goal is to keep the cancer from coming back while reducing side effects. About 30 adult…

This study tests a chemotherapy drug called CPX-351 as a maintenance treatment for adults with acute myeloid leukemia (AML) who are in remission but cannot have a bone marrow transplant. The goal is to find a safe dose and see if it helps keep the cancer from coming back. About 2…

This study tests whether giving chemotherapy plus an immunotherapy drug (cemiplimab) before surgery can help people with stage 3 non-small cell lung cancer that has spread to certain lymph nodes. About 21 adults will receive four cycles of the combination, then have surgery to re…

This study tests whether a telehealth program can help cancer survivors prevent mouth sores, gum disease, and tooth decay, and improve their quality of life. One hundred cancer survivors who finished treatment at least 6 months ago will either get the telehealth program or usual …

This study tests whether the drug azeliragon can reduce heart damage caused by chemotherapy in women with early-stage breast cancer. About 48 participants will receive azeliragon alongside standard chemo to see if it is safe and helps protect the heart and thinking abilities. The…

This study compares two smoking cessation programs for 1,188 people who are getting lung cancer screening. Participants must be current smokers aged 50-80 with a heavy smoking history. The goal is to see which program helps more people quit smoking for good, using both self-repor…

This early-phase study tests the safety and best dose of a new drug combination (NEROFE and doxorubicin) in adults with advanced solid tumors that have a KRAS mutation and ST2 protein. About 24 participants whose cancer has worsened after standard treatments will receive weekly d…

This study tests whether an 8-week Mindful Self-Compassion training program can reduce symptoms of anxiety and depression. It compares delivering the program in-person versus through videoconference. The study involves 80 adults diagnosed with anxiety disorders or major depressio…

This study is testing whether a web-based program called SHUTi can help Black/African American prostate cancer survivors sleep better. About 40 people will be randomly assigned to either the SHUTi program or an educational website. The goal is to see if the online treatment is pr…

This study tests whether offering combined breast and colon cancer screening, along with genetic risk assessment, helps more women get the right tests on time. Researchers will compare bundled navigation to single-cancer navigation in 820 Black and Hispanic women aged 45-74. The …