Fondazione Irccs Ca' Granda, Ospedale Maggiore Policlinico

This study looks at how well the drug daratumumab works and how safe it is for people with a rare blood clotting disorder called immune-mediated thrombotic thrombocytopenic purpura (iTTP). It includes 40 adults whose disease did not get better with standard treatments or who coul…

This study tests whether eye drops made from umbilical cord blood plasma can relieve dry eye disease better than standard artificial tears. About 100 adults with moderate to severe dry eye will receive either the cord blood drops or artificial tears for two months. The goal is to…

This study looks at how certain genes increase the risk of liver cancer (hepatocellular carcinoma) in people with nonalcoholic fatty liver disease (NAFLD). Researchers will follow 500 adults aged 45-75 with NAFLD to understand genetic factors and develop a risk score. The goal is…

This study is testing whether tiny particles in the blood, called extracellular vesicles, can predict nerve damage caused by chemotherapy. Researchers will follow 120 adults with various cancers who are receiving specific chemotherapy drugs. Participants will give blood samples a…

This study aims to find genetic differences that make some people with fatty liver disease develop severe liver damage or cancer. Researchers will analyze DNA from blood and liver samples of 2,880 adults aged 40-70 with advanced disease or metabolic risk factors. The goal is to c…

This study uses tiny, lab-grown liver models called organoids to understand how a specific gene change (PNPLA3 I148M) contributes to non-alcoholic steatohepatitis (NASH), a serious form of fatty liver disease. Researchers will create these models from liver cells donated by 60 ad…

This study follows 650 women with endometriosis who want to have children after treatment. It compares pregnancy rates and use of fertility treatments between those who had medical therapy versus surgery. The goal is to help doctors and patients make better-informed decisions abo…

This study looks at special cells from blood vessels (ECFCs) in people with von Willebrand disease, acquired von Willebrand syndrome, and healthy volunteers. Researchers want to see how these cells make and release a key clotting protein. The goal is to better understand the dise…

This study looks at how a person's genes and their environment (like drinking alcohol) work together to cause liver cancer in people with alcohol-related liver disease. Researchers will study 1,000 participants to find new genetic variants that increase cancer risk. The goal is t…

This study aims to create a rapid test that measures T-cell responses in people with chronic hepatitis B (HBV) or combined hepatitis B and D (HBV/HDV). By analyzing immune system activity, researchers hope to better understand how the disease progresses and how patients respond t…

This study looks at whether using a mix of brain scans, spinal fluid tests, and thinking/movement assessments can better diagnose idiopathic normal pressure hydrocephalus (iNPH) and identify who will benefit from shunt surgery. Researchers will follow 116 adults aged 60+ with sus…

This study aims to see if a lab-grown cell system can detect a substance in the blood that causes protein leakage in the urine of people with a kidney condition called nephrotic syndrome. Researchers will compare blood and urine samples from 150 participants—including those with …

This study looks at whether kidney failure changes how well the flu vaccine works in people on dialysis. Researchers will compare the immune response of 146 dialysis patients and healthy volunteers after they get the flu shot. Participants will give blood samples over several mon…

This study looks at whether blocking two proteins, SUV420H1 and SUV420H2, in liver cells can protect against nonalcoholic fatty liver disease (NAFLD). Researchers will test this in mice on a fatty diet, analyze human genetic data from large health databases, and try a new approac…

This study looks at how genes influence fatty liver disease and related heart and blood clot problems. Researchers will study 2500 blood donors aged 40-65 who are overweight or have related health issues. The goal is to use genetic information to better predict who is at risk and…

This study looks for hidden genetic causes of cholestatic liver disease in adults whose diagnosis remains unclear after standard tests. Researchers will use whole-genome sequencing to analyze DNA from 60 participants. The goal is to find rare gene changes that explain the disease…

This study enrolls women aged 50 and older to measure the size of the abdominal aorta using ultrasound. Researchers want to define what is normal for women and identify sex-specific risk factors for aortic aneurysm and hardening of the arteries. No treatment or medication is give…

This observational study aims to understand how the immune system responds to hepatitis D virus (HDV) in people with chronic HBV-HDV infection. Researchers will measure HDV-specific T cell responses in 192 participants before and during treatment with bulevirtide. The goal is to …